دورية أكاديمية
High Prevalence of Previously Undiagnosed Axial Spondyloarthritis in Patients Referred With Anterior Uveitis and Chronic Back Pain: The SpEYE Study.
| العنوان: | High Prevalence of Previously Undiagnosed Axial Spondyloarthritis in Patients Referred With Anterior Uveitis and Chronic Back Pain: The SpEYE Study. |
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| المؤلفون: | van Bentum RE; R.E. van Bentum, MD, I.E. van der Horst-Bruinsma, MD, PhD, Department of Rheumatology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam; Irene.vanderHorst-Bruinsma@radboudumc.nl., Verbraak FD; F.D. Verbraak, MD, PhD, H.S. Tan, MD, PhD, Department of Ophthalmology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam., Wolf S; S. Wolf, MD, Department of Ophthalmology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, and Department of Ophthalmology, Bergman Clinics, Zaandam., Ongkosuwito J; J. Ongkosuwito, MD, PhD, Department of Ophthalmology, Onze Lieve Vrouwe Gasthuis, Amsterdam., Boers M; M. Boers, MD, PhD, Department of Rheumatology, and Department of Epidemiology & Data Science, Amsterdam Public Health, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands., Tan HS; F.D. Verbraak, MD, PhD, H.S. Tan, MD, PhD, Department of Ophthalmology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam., van der Horst-Bruinsma IE; R.E. van Bentum, MD, I.E. van der Horst-Bruinsma, MD, PhD, Department of Rheumatology, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam. |
| المصدر: | The Journal of rheumatology [J Rheumatol] 2022 Jul; Vol. 49 (7), pp. 680-687. Date of Electronic Publication: 2022 Feb 15. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0315-162X (Print) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Toronto : Journal Of Rheumatology Publishing Co Original Publication: Toronto. |
| مواضيع طبية MeSH: | Axial Spondyloarthritis* , Spondylarthritis*/complications , Spondylarthritis*/diagnosis , Spondylarthritis*/epidemiology , Spondylitis, Ankylosing*/complications , Uveitis, Anterior*/complications , Uveitis, Anterior*/diagnosis , Uveitis, Anterior*/epidemiology, Acute Disease ; Adult ; Back Pain/epidemiology ; Back Pain/etiology ; Delayed Diagnosis/adverse effects ; Female ; HLA-B27 Antigen ; Humans ; Male ; Middle Aged ; Prevalence ; Referral and Consultation |
| مستخلص: | Objective: To reduce the diagnostic delay in axial spondyloarthritis (axSpA), guidelines recommend referring patients with acute anterior uveitis (AAU) and chronic back pain (CBP) to a rheumatologist. This observational study in daily practice evaluated the prevalence of previously unrecognized axSpA in patients with AAU who were referred by ophthalmologists because of concurrent CBP. Methods: All patients with AAU referred with CBP (≥ 3 months, age of onset < 45 yrs) from 5 ophthalmology clinics underwent rheumatologic assessment, including pelvic radiographs. Patients with previously diagnosed rheumatic disease and AAU due to other causes were excluded. The primary endpoint was a clinical axSpA diagnosis by the rheumatologist. Results: Eighty-one patients fulfilled the referral criteria (52% male, 56% HLA-B27 positive, median age 41 yrs, median CBP duration 10 yrs). In total, 58% (n = 47) had recurring AAU, of whom 87% already had CBP during previous AAU attacks. After assessment, 23% (n = 19) of patients were clinically diagnosed with definite axSpA (10/19 radiographic), 40% (n = 32) with suspicion of axSpA, and 37% (n = 30) with no axSpA. AxSpA was diagnosed more often in men (33% of the men vs 13% of the women). Conclusion: A high prevalence of axSpA was found in patients with AAU referred because of CBP. There was substantial diagnostic delay in the majority of patients with recurring AAU, as many already had CBP during previous AAU flares. In AAU, screening for CBP and prompt referral has a high diagnostic yield and should consistently be promoted among ophthalmologists. (Copyright © 2022 by the Journal of Rheumatology.) |
| فهرسة مساهمة: | Keywords: anterior uveitis; back pain; ophthalmologists; spondylarthropathies |
| المشرفين على المادة: | 0 (HLA-B27 Antigen) |
| تواريخ الأحداث: | Date Created: 20220216 Date Completed: 20220707 Latest Revision: 20220814 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3899/jrheum.210345 |
| PMID: | 35169057 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0315-162X |
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| DOI: | 10.3899/jrheum.210345 |