دورية أكاديمية
أعرض في EDS

The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers.

التفاصيل البيبلوغرافية
العنوان: The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers.
المؤلفون: de Wolde SD; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Hyperbaric Medicine, Amsterdam UMC, Location AMC, Amsterdam, Netherlands., Hulskes RH; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Surgery, Amsterdam UMC, Location AMC, Amsterdam, Netherlands., de Jonge SW; Department of Surgery, Amsterdam UMC, Location AMC, Amsterdam, Netherlands., Hollmann MW; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., van Hulst RA; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Hyperbaric Medicine, Amsterdam UMC, Location AMC, Amsterdam, Netherlands., Weenink RP; Department of Anesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Hyperbaric Medicine, Amsterdam UMC, Location AMC, Amsterdam, Netherlands., Kox M; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands.
المصدر: Frontiers in physiology [Front Physiol] 2022 Jan 31; Vol. 13, pp. 826163. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Hyperbaric oxygen therapy (HBOT) consists of breathing 100% oxygen under increased ambient pressure. There are indications that HBOT induces oxidative stress and activates immune pathways. However, previous research on immunological effects of HBOT has mainly been established in in vitro experiments and selected patient populations, limiting generalizability and increasing the chances of confounding by comorbidities and specific patient-related factors. More insight into the immunological effects of HBOT would aid investigation and comprehension of potentially novel treatment applications. Therefore, in this study, we investigated the effects of three 110-min HBOT-sessions with 24-h intervals on immunological parameters in healthy, young, male volunteers. Blood samples were obtained before and after the first and third HBOT sessions. We assessed neutrophilic reactive oxygen species (ROS) production, systemic oxidative stress [plasma malondialdehyde (MDA) concentrations] as well as neutrophil phagocytic activity, plasma concentrations of tumor necrosis factor (TNF), interleukin (IL)-6, IL-8, and IL-10, and production of TNF, IL-6, and IL-10 by leukocytes ex vivo stimulated with the Toll-like receptor (TLR) ligands lipopolysaccharide (TLR4) and Pam3Cys (TLR2). We observed decreased neutrophilic ROS production and phagocytosis following the second HBOT session, which persisted after the third session, but no alterations in MDA concentrations. Furthermore, plasma concentrations of the investigated cytokines were unaltered at all-time points, and ex vivo cytokine production was largely unaltered over time as well. These results indicate no induction of systemic oxidative stress or a systemic inflammatory response after repeated HBOT in healthy volunteers but may suggest exhaustion of ROS generation capacity and phagocytosis.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 de Wolde, Hulskes, de Jonge, Hollmann, van Hulst, Weenink and Kox.)
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فهرسة مساهمة: Keywords: cytokines; healthy volunteers; hyperbaric oxygen therapy; hyperbaric oxygenation; immune response; immune system; inflammation; oxidative stress
تواريخ الأحداث: Date Created: 20220217 Latest Revision: 20220219
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8843016
DOI: 10.3389/fphys.2022.826163
PMID: 35173631
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2022.826163