دورية أكاديمية
Neutrophil-Platelet Interactions as Novel Treatment Targets in Cardiovascular Disease.
| العنوان: | Neutrophil-Platelet Interactions as Novel Treatment Targets in Cardiovascular Disease. |
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| المؤلفون: | Kaiser R; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Berlin, Germany., Escaig R; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Berlin, Germany., Erber J; Department of Internal Medicine II, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany., Nicolai L; Department of Medicine I, University Hospital, Ludwig-Maximilians University Munich, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK, German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Berlin, Germany. |
| المصدر: | Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Jan 31; Vol. 8, pp. 824112. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Neutrophils and platelets are among the most abundant cell types in peripheral blood and characterized by high plasticity and a readily available reservoir of surface proteins and secretable granule contents. Receptor-mediated activation and granule release predispose both cell types for rapid responses to various stimuli. While neutrophils provide the first line of defense to microbial infections and platelets are known for their aggregatory functions in hemostasis and thrombosis, research of the past decade has highlighted that both cell types jointly shape local and systemic immune responses and clot formation alike. Concomitant activation of neutrophils and platelets has been observed in a variety of cardiovascular diseases, including arterial and venous thrombosis, atherosclerosis as well as myocardial infarction and ischemia-reperfusion injury. In this review, we describe the mechanisms by which neutrophils and platelets interact physically, how release of granule contents and soluble molecules by either cell type affects the other and how this mutual activation supports the efficacy of immune responses. We go on to describe how activated platelets contribute to host defense by triggering neutrophil extracellular trap (NET) formation in a process termed immunothrombosis, which in turn promotes local platelet activation and coagulation. Further, we review current evidence of hazardous overactivation of either cell type and their respective role in cardiovascular disease, with a focus on thrombosis, myocardial infarction and ischemia-reperfusion injury, and describe how neutrophils and platelets shape thromboinflammation in COVID-19. Finally, we provide an overview of therapeutic approaches targeting neutrophil-platelet interactions as novel treatment strategy in cardiovascular disease. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Kaiser, Escaig, Erber and Nicolai.) |
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| فهرسة مساهمة: | Keywords: NETosis; cardiovascular disease; neutrophil; platelet; thrombosis |
| تواريخ الأحداث: | Date Created: 20220217 Latest Revision: 20220219 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8841491 |
| DOI: | 10.3389/fcvm.2021.824112 |
| PMID: | 35174225 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2297-055X |
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| DOI: | 10.3389/fcvm.2021.824112 |