دورية أكاديمية
Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats.
| العنوان: | Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats. |
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| المؤلفون: | Nunes LF; Department of Genetics and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil., Antunes FTT; Postgraduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil., Souza AH; Postgraduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil., Teixeira VS; Department of Genetics and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil., Wiilland EF; Department of Genetics and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil., Picada JN; Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil., Brum LFDS; Department of Genetics and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil. |
| المصدر: | Acta scientiarum polonorum. Technologia alimentaria [Acta Sci Pol Technol Aliment] 2022 Jan-Mar; Vol. 21 (1), pp. 101-109. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu Country of Publication: Poland NLM ID: 101295615 Publication Model: Print Cited Medium: Internet ISSN: 1898-9594 (Electronic) Linking ISSN: 16440730 NLM ISO Abbreviation: Acta Sci Pol Technol Aliment Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Poznań : Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu |
| مواضيع طبية MeSH: | Cordia*, Animals ; Body Weight ; DNA Damage ; Diet ; Diet, High-Fat ; Obesity ; Rats |
| مستخلص: | Background: Overweight and obesity are associated with deaths and diseases worldwide. Cordia ecalyculata is a plant marketed as a slimmer. Methods: The study evaluated the anti-obesity effects of the dry extract from C. ecalyculata in rats fed with a standard diet (STD) or cafeteria diet (CD) receiving the dry extract from C. ecalyculata at 500, 1000, and 2000 mg/kg for 40 days. Furthermore, it evaluated the slimming effect on diet-induced obese rats by the treatment with the same doses for 30 days. The bodyweight of the rats, as well as the intake of food, was measured. Blood samples were collected to determine the liver function (albumin, alanine transaminase (ALT), alkaline phosphatase (ALP), glucose), renal function (urea and creatinine), and lipid profile (cholesterol, triglycerides). Results: The genotoxic effect in peripheral blood was assessed through the comet assay. A lower C. ecalyculata dose significantly prevented the weight gain in rats fed with STD and CD and decreased body weight and intake food of obese rats. The biochemical parameters were not altered, except to increase the serum albumin. Only the higher dose induced DNA damage when evaluated in rats fed with CD in the slimming evaluation model used. Conclusions: These results reinforce the extract as an anti-obesity and slimming supplement. |
| فهرسة مساهمة: | Keywords: Cordia ecalyculata; comet assay; hepatic profile; obesity |
| تواريخ الأحداث: | Date Created: 20220217 Date Completed: 20220218 Latest Revision: 20220218 |
| رمز التحديث: | 20231215 |
| DOI: | 10.17306/J.AFS.0998 |
| PMID: | 35174692 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1898-9594 |
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| DOI: | 10.17306/J.AFS.0998 |