دورية أكاديمية
أعرض في EDS

Siolmatra brasiliensis stem extract ameliorates antioxidant defenses and mitigates glycoxidative stress in mice with high-fat diet-induced obesity.

التفاصيل البيبلوغرافية
العنوان: Siolmatra brasiliensis stem extract ameliorates antioxidant defenses and mitigates glycoxidative stress in mice with high-fat diet-induced obesity.
المؤلفون: Talpo TC; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Motta BP; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Oliveira JO; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Figueiredo ID; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Pinheiro CG; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Dos Santos CHC; Federal Rural University of Rio de Janeiro (UFRRJ), Institute of Exact Sciences, Department of Chemistry, Seropédica, Rio de Janeiro, Brazil., Carvalho MG; Federal Rural University of Rio de Janeiro (UFRRJ), Institute of Exact Sciences, Department of Chemistry, Seropédica, Rio de Janeiro, Brazil., Brunetti IL; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil., Baviera AM; São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil. Electronic address: amanda.baviera@unesp.br.
المصدر: Obesity research & clinical practice [Obes Res Clin Pract] 2022 Mar-Apr; Vol. 16 (2), pp. 130-137. Date of Electronic Publication: 2022 Feb 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101303911 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1871-403X (Print) Linking ISSN: 1871403X NLM ISO Abbreviation: Obes Res Clin Pract Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, 2007-
مواضيع طبية MeSH: Glucose Intolerance*/drug therapy , Glucose Intolerance*/metabolism , Insulin Resistance*, Animals ; Antioxidants/pharmacology ; Aryldialkylphosphatase ; Biomarkers/metabolism ; Diet, High-Fat ; Glucose/metabolism ; Humans ; Lipid Peroxidation ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/drug therapy ; Obesity/metabolism ; Oxidative Stress ; Plant Extracts/pharmacology ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/pharmacology ; Thiobarbituric Acid Reactive Substances/metabolism ; Thiobarbituric Acid Reactive Substances/pharmacology
مستخلص: Background: Obesity is accompanied by insulin resistance and glucose intolerance, which favor the onset of complications related to oxidative stress. The aim of this study was to investigate the effects and underlying mechanisms of hydroethanolic extract from Siolmatra brasiliensis stems on insulin resistance, glucose intolerance, advanced glycation end product (AGE) formation, and oxidative stress in mice with induced obesity.
Methods: C57BL-6 J mice were fed a high-fat diet for 14 weeks and treated with 125 or 250 mg/kg S. brasiliensis extract during the last 7 weeks. The study assessed glucose tolerance and insulin sensitivity, lipid profile, plasma levels of thiobarbituric acid reactive substances (TBARS, biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 (PON1) activity (antioxidant enzyme). The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver and kidneys were also investigated.
Results: Siolmatra brasiliensis extract had antiobesogenic effects; improved insulin sensitivity and glucose tolerance; decreased the total plasma cholesterol levels; decreased the levels of glycoxidative stress biomarkers, including AGEs (plasma, liver, kidneys) and TBARS (liver, kidneys); and also improved endogenous antioxidant defenses by increasing the activities of PON1 (plasma), SOD (kidneys), CAT (liver, kidneys), and GSH-Px (kidneys).
Conclusion: This study expands on our knowledge about the pharmacological properties of S. brasiliensis and substantiates the potential of this plant species to be used as a complementary therapeutic agent to alleviate the metabolic dysfunctions resulting from dyslipidemia and glycoxidative stress.
(Copyright © 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Advanced glycation end products; Antioxidant defenses; Cucurbitaceae; Lipid peroxidation; Obesity
المشرفين على المادة: 0 (Antioxidants)
0 (Biomarkers)
0 (Plant Extracts)
0 (Thiobarbituric Acid Reactive Substances)
EC 1.15.1.1 (Superoxide Dismutase)
EC 3.1.8.1 (Aryldialkylphosphatase)
EC 3.1.8.1 (PON1 protein, human)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20220220 Date Completed: 20220426 Latest Revision: 20220613
رمز التحديث: 20221213
DOI: 10.1016/j.orcp.2022.02.004
PMID: 35183472
قاعدة البيانات: MEDLINE
الوصف
تدمد:1871-403X
DOI:10.1016/j.orcp.2022.02.004