دورية أكاديمية
أعرض في EDS

Hypothermic machine perfusion for liver graft preservation.

التفاصيل البيبلوغرافية
العنوان: Hypothermic machine perfusion for liver graft preservation.
المؤلفون: Amin A; Division of Abdominal Transplant Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Panayotova G, Guarrera JV
المصدر: Current opinion in organ transplantation [Curr Opin Organ Transplant] 2022 Apr 01; Vol. 27 (2), pp. 98-105.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9717388 Publication Model: Print Cited Medium: Internet ISSN: 1531-7013 (Electronic) Linking ISSN: 10872418 NLM ISO Abbreviation: Curr Opin Organ Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Philadelphia, PA : Rapid Science Publishers,
مواضيع طبية MeSH: Liver Transplantation*/adverse effects, Humans ; Liver/surgery ; Organ Preservation/adverse effects ; Perfusion/adverse effects ; Tissue Donors
مستخلص: Purpose of Review: Ex-vivo machine perfusion has emerged as a promising alternative to static cold storage (SCS) for preservation of liver grafts over the last decade. This review describes the mechanistic benefits associated with hypothermic machine perfusion (HMP) for preservation of liver grafts and highlights clinical outcomes of liver transplantation using HMP technology.
Recent Findings: Over the last decade, several single-centre studies have shown decreased biliary complications, decreased early allograft dysfunction (EAD) rates and improved patient survival in liver transplant recipients after application of HMP for liver graft preservation. This has led to initiation of prospective, multicentre, randomized controlled trials (RCTs) in both Europe and North America focused on clinical outcomes in liver transplant recipients using HMP-preserved liver grafts. In addition, recent single-centre studies have shown the utility of perfusate biomarker analysis during HMP in predicting EAD after liver transplantation.
Summary: HMP technology has potential to increase the available donor liver organ pool for liver transplant recipients and improve clinical outcomes after liver transplantation. Broader clinical application of HMP in resuscitation and preservation of liver grafts is anticipated over the next decade once regulatory, logistical and financial challenges are overcome.
(Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20220220 Date Completed: 20220504 Latest Revision: 20230917
رمز التحديث: 20231215
DOI: 10.1097/MOT.0000000000000973
PMID: 35184093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-7013
DOI:10.1097/MOT.0000000000000973