دورية أكاديمية
أعرض في EDS

HPLC-DAD analysis and antimicrobial activities of Spondias mombin L. (Anacardiaceae).

التفاصيل البيبلوغرافية
العنوان: HPLC-DAD analysis and antimicrobial activities of Spondias mombin L. (Anacardiaceae).
المؤلفون: de Freitas MA; Federal University of Pernambuco (UFPE), Recife, PE Brazil., da Cruz RP; Regional University of Cariri (URCA), Crato, CE Brazil., Dos Santos ATL; Regional University of Cariri (URCA), Crato, CE Brazil., Almeida-Bezerra JW; Regional University of Cariri (URCA), Crato, CE Brazil., Machado AJT; Regional University of Cariri (URCA), Crato, CE Brazil., Dos Santos JFS; Regional University of Cariri (URCA), Crato, CE Brazil., Rocha JE; Regional University of Cariri (URCA), Crato, CE Brazil., Boligon AA; Federal University of Santa Maria (UFSM), Santa Maria, RS Brazil., Bezerra CF; Federal University of Pernambuco (UFPE), Recife, PE Brazil., de Freitas TS; Regional University of Cariri (URCA), Crato, CE Brazil., do Nascimento Silva MK; Regional University of Cariri (URCA), Crato, CE Brazil., Mendonça ACAM; Regional University of Cariri (URCA), Crato, CE Brazil., da Costa JGM; Regional University of Cariri (URCA), Crato, CE Brazil., Coutinho HDM; Regional University of Cariri (URCA), Crato, CE Brazil., da Cunha FAB; Regional University of Cariri (URCA), Crato, CE Brazil., Filho JR; Oswaldo Cruz Foundation, Salvador, BA Brazil., Morais-Braga MFB; Regional University of Cariri (URCA), Crato, CE Brazil.
المصدر: 3 Biotech [3 Biotech] 2022 Mar; Vol. 12 (3), pp. 61. Date of Electronic Publication: 2022 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101565857 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2190-572X (Print) Linking ISSN: 21905738 NLM ISO Abbreviation: 3 Biotech Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer
مستخلص: Spondias mombin is used in the folk medicine for the treatment of diarrhea and dysentery, indicating that extracts obtained from this species may present pharmacological activities against pathogenic microorganisms. The purpose of this work was to investigate the chemical composition and evaluate the antimicrobial activity of extracts obtained from the leaves (aqueous) and bark (hydroethanolic) of S. mombin both as single treatments and in combination with conventional drugs. Following a qualitative chemical prospection, the extracts were analyzed by HPLC-DAD. The antimicrobial activities were evaluated by microdilution. The combined activity of drugs and extracts was verified by adding a subinhibitory concentration of the extract in the presence of variable drug concentrations. The Minimum Fungicidal Concentration (MFC) was determined by a subculture of the microdilution test, while the effect of the in vitro treatments on morphological transition was analyzed by subculture in moist chambers. While the qualitative analysis detected the presence of phenols and flavonoids, the HPLC analysis identified quercetin, caffeic acid, and catechin as major components in the leaf extract, whereas kaempferol and quercetin were found as major compounds in the bark extract. The extracts showed effective antibacterial activities only against the Gram-negative strains. With regard to the combined activity, the leaf extract potentiated the action of gentamicin and imipenem (against Staphylococcus aureus ), while the bark extract potentiated the effect of norfloxacin (against S. aureus ), imipenem (against Escherichia coli ), and norfloxacin (against Pseudomonas aeruginosa ). A more significant antifungal (fungistatic) effect was achieved with the bark extract (even though at high concentrations), which further enhanced the activity of fluconazole. The extracts also inhibited the emission of filaments by Candida albicans and Candida tropicalis . Together, these findings suggest that that the extract constituents may act by favoring the permeability of microbial cells to conventional drugs, as well as by affecting virulence mechanisms in Candida strains .
(© King Abdulaziz City for Science and Technology 2022.)
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فهرسة مساهمة: Keywords: Antibacterial; Antifungal; Antimicrobial resistance; Phytochemicals
تواريخ الأحداث: Date Created: 20220221 Latest Revision: 20230302
رمز التحديث: 20230302
مُعرف محوري في PubMed: PMC8818589
DOI: 10.1007/s13205-022-03126-1
PMID: 35186658
قاعدة البيانات: MEDLINE
الوصف
تدمد:2190-572X
DOI:10.1007/s13205-022-03126-1