دورية أكاديمية
Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation.
| العنوان: | Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation. |
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| المؤلفون: | Isakov O; Department of Internal Medicine 'T', Tel Aviv Souraski Medical Center, Tel Aviv University, Tel Aviv, Israel., Patibandla BK; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA., Christopher KB; Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Chandraker A; Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Transplant Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Hod T; Department of Nephrology, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.; Renal Transplant Center, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel. |
| المصدر: | Kidney & blood pressure research [Kidney Blood Press Res] 2022; Vol. 47 (5), pp. 341-353. Date of Electronic Publication: 2022 Feb 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 9610505 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0143 (Electronic) Linking ISSN: 14204096 NLM ISO Abbreviation: Kidney Blood Press Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, c1996- |
| مواضيع طبية MeSH: | Graft Rejection* , Kidney Transplantation*/adverse effects, Female ; Graft Survival ; Humans ; Immunosuppressive Agents/adverse effects ; Magnesium ; Middle Aged ; Retrospective Studies |
| مستخلص: | Background: Post-transplant hypomagnesemia is commonly observed among patients prescribed calcineurin inhibitor (CNIs). Methods: We conducted a retrospective single-center analysis (2000-2013, N = 726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium (Mg) level of all measured Mg levels from 1 month to 1 year posttransplant was calculated. Results: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall mortality, and death with a functioning graft increased by 11%, 14%, and 12%, respectively (p < 0.01). In a multivariate model, patients with median Mg level ≥1.7 mg/dL had a reduced overall survival rate (HR 1.57, 95% CI: 1.04-2.38, p = 0.033) compared to those with median Mg level <1.7 mg/dL. This association was observed in subgroups of patients above 60 years old, in those who had a slow graft function (SGF) and in females. Conclusions: Posttransplant hypomagnesemia is associated with better patient and allograft survival up to 10 years posttransplant. This relationship remained significant after accounting for baseline allograft function, presence of SGF and CNI trough levels. (© 2022 The Author(s). Published by S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Calcineurin inhibitors; Hypomagenesemia; Mortality; Renal allograft survival |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) I38ZP9992A (Magnesium) |
| تواريخ الأحداث: | Date Created: 20220223 Date Completed: 20220517 Latest Revision: 20220517 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1159/000522233 |
| PMID: | 35196662 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0143 |
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| DOI: | 10.1159/000522233 |