دورية أكاديمية
أعرض في EDS

Effect of triclosan-coated sutures for abdominal wound closure on the incidence of abdominal wound dehiscence: a protocol for an individual participant data meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Effect of triclosan-coated sutures for abdominal wound closure on the incidence of abdominal wound dehiscence: a protocol for an individual participant data meta-analysis.
المؤلفون: Timmer AS; Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam Infection and Immunity, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Wolfhagen N; Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam Infection and Immunity, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Pianka F; Department of General, Visceral and Transplantation Surgery, UniversitatsKlinikum Heidelberg, Heidelberg, Germany., Knebel P; Department of General, Visceral and Transplantation Surgery, UniversitatsKlinikum Heidelberg, Heidelberg, Germany., Justinger C; Department of Surgery, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe, Germany., Stravodimos C; Department of Surgery, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe, Germany., Ichida K; Department of Surgery, Jichi Medical University, Saitama, Japan., Rikiyama T; Department of Surgery, Jichi Medical University, Saitama, Japan., Baracs J; Department of Surgery, University of Pecs, Pecs, Hungary., Vereczkei A; Department of Surgery, University of Pecs, Pecs, Hungary., Gianotti L; Department of Surgery, San Gerardo Hospital, Monza, Italy., Ruiz-Tovar J; Department of Surgery, Rey Juan Carlos University, Madrid, Spain., Hernández AM; Department of Humanities and Social Sciences, University Isabel I, Burgos, Spain., Nakamura T; Department of Surgery, Hokkaido University, Sapporo, Japan., Dijkgraaf MGW; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam Public Health, University of Amsterdam, Amsterdam, The Netherlands., Boermeester MA; Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam Infection and Immunity, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands m.a.boermeester@amsterdamumc.nl., de Jonge SW; Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam Infection and Immunity, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands.
المصدر: BMJ open [BMJ Open] 2022 Feb 23; Vol. 12 (2), pp. e054534. Date of Electronic Publication: 2022 Feb 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
مواضيع طبية MeSH: Abdominal Injuries* , Abdominal Wound Closure Techniques*/adverse effects , Triclosan*, Abdomen/surgery ; Adult ; Humans ; Incidence ; Meta-Analysis as Topic ; Surgical Wound Dehiscence/epidemiology ; Surgical Wound Dehiscence/prevention & control ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control ; Sutures/adverse effects ; Systematic Reviews as Topic
مستخلص: Introduction: Acute abdominal wound dehiscence (AWD) or burst abdomen is a severe complication after abdominal surgery with an incidence up to 3.8%. Surgical site infection (SSI) is the biggest risk factor for the development of AWD. It is strongly suggested that the use of triclosan-coated sutures (TCS) for wound closure reduces the risk of SSI. We hypothesise that the use of TCS for abdominal wound closure may reduce the risk of AWD. Current randomised controlled trials (RCTs) lack power to investigate this. Therefore, the purpose of this individual participant data meta-analysis is to evaluate the effect of TCS for abdominal wound closure on the incidence of AWD.
Methods and Analysis: We will conduct a systematic review of Medline, Embase and Cochrane Central Register of Controlled Trials for RCTs investigating the effect of TCS compared with non-coated sutures for abdominal wound closure in adult participants scheduled for open abdominal surgery. Two independent reviewers will assess eligible studies for inclusion and methodological quality. Authors of eligible studies will be invited to collaborate and share individual participant data. The primary outcome will be AWD within 30 days after surgery requiring reoperation. Secondary outcomes include SSI, all-cause reoperations, length of hospital stay and all-cause mortality within 30 days after surgery. Data will be analysed with a one-step approach, followed by a two-step approach. In the one-step approach, treatment effects will be estimated as a risk ratio with corresponding 95% CI in a generalised linear mixed model framework with a log link and binomial distribution assumption. The quality of evidence will be judged using the Grading of Recommendations Assessment Development and Evaluation approach.
Ethics and Dissemination: The medical ethics committee of the Amsterdam UMC, location AMC in the Netherlands waived the necessity for a formal approval of this study, as this research does not fall under the Medical Research involving Human Subjects Act. Collaborating investigators will deidentify data before sharing. The results will be submitted to a peer-reviewed journal.
Prospero Registration Number: CRD42019121173.
Competing Interests: Competing interests: AST, NW, FP, PK, CS, KI, TR, JB, AV, LG, JR-T, AMH, TN, MGWD and SWdJ declare no conflict of interest. CJ is an advisory board member of Johnson & Johnson/Ethicon. MAB reports receiving institutional grants from J&J/Ethicon, KCI/3M, and New Compliance; and is an advisory board member and/or speaker and/or instructor for KCI/3M, Johnson & Johnson/Ethicon, LifeCell/Allergan, Bard, Gore, TelaBio, Medtronic, GD Medical, and Smith & Nephew.
(© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: infection control*; surgery*; wound management*
المشرفين على المادة: 4NM5039Y5X (Triclosan)
تواريخ الأحداث: Date Created: 20220224 Date Completed: 20220411 Latest Revision: 20220502
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8867322
DOI: 10.1136/bmjopen-2021-054534
PMID: 35197346
قاعدة البيانات: MEDLINE
الوصف
تدمد:2044-6055
DOI:10.1136/bmjopen-2021-054534