دورية أكاديمية
Subsequent pregnancy and long-term safety after breast cancer: a retrospective analysis of Korean health insurance data.
| العنوان: | Subsequent pregnancy and long-term safety after breast cancer: a retrospective analysis of Korean health insurance data. |
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| المؤلفون: | Kang M; Artificial Intelligence and Big-Data Convergence Center, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea., Chun YS; Department of General Surgery, Breast Cancer Center, Gachon University Gil Medical Center, Incheon, Korea., Park HK; Department of General Surgery, Breast Cancer Center, Gachon University Gil Medical Center, Incheon, Korea., Cho EK; Department of Medical Oncology, Gachon University Gil Medical Center, Incheon, Korea., Jung J; Artificial Intelligence and Big-Data Convergence Center, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.; Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Korea., Kim Y; Department of General Surgery, Breast Cancer Center, Gachon University Gil Medical Center, Incheon, Korea. |
| المصدر: | Annals of surgical treatment and research [Ann Surg Treat Res] 2022 Feb; Vol. 102 (2), pp. 73-82. Date of Electronic Publication: 2022 Feb 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Surgical Society Country of Publication: Korea (South) NLM ID: 101622895 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2288-6575 (Print) Linking ISSN: 22886575 NLM ISO Abbreviation: Ann Surg Treat Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Surgical Society, [2014]- |
| مستخلص: | Purpose: Long-term safety of pregnancy after breast cancer (BC) remains controversial, especially with respect to BC biological subtypes. Methods: We analyzed a population-based retrospective cohort with BC from 2002 to 2017. Patient-level 1:1 matching was performed between pregnant and nonpregnant women. The study population was categorized into 6 biological subtypes based on the combination of prescribed therapies. Subanalyses were performed considering the time to pregnancy after BC diagnosis, systemic therapy, and pregnancy outcomes. Results: We identified 544 matched women with BC, who were assigned to the pregnant (cases, n = 272) or nonpregnant group (controls, n = 272) of similar characteristics, adjusted for guaranteed bias. These patients were followed up for 10 years, or disease and mortality occurrence after the diagnosis of BC. Survival estimates were calculated. The actuarial 10-year overall survival (OS) rates were 97.4% and 91.9% for pregnant and nonpregnant patients, respectively. The pregnant group showed significantly better OS (adjusted hazard ratio [aHR], 0.29; 95% confidence interval [CI], 0.12-0.68; P = 0.005) and did not have a significantly inferior disease-free survival (aHR, 1.10; 95% CI, 0.61-1.99; P = 0.760). Conclusion: Consistent outcomes were observed in every subgroup analysis. Our observational data provides reassuring evidence on the long-term safety of pregnancy in young patients with BC regardless of the BC biological subtype. Competing Interests: Conflict of Interest: No potential conflict of interest relevant to this article was reported. (Copyright © 2022, the Korean Surgical Society.) |
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| فهرسة مساهمة: | Keywords: Breast neoplasms; Korea; Long term effects; Pregnancy; Retrospective studies |
| تواريخ الأحداث: | Date Created: 20220224 Latest Revision: 20220502 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8831090 |
| DOI: | 10.4174/astr.2022.102.2.73 |
| PMID: | 35198510 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2288-6575 |
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| DOI: | 10.4174/astr.2022.102.2.73 |