دورية أكاديمية
أعرض في EDS

Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity.

التفاصيل البيبلوغرافية
العنوان: Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity.
المؤلفون: Oliveira VDS; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Cruz MMD; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Bezerra GS; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Silva NESE; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Nogueira FHA; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Chaves GM; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil., Sobrinho JLS; Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife 50740-520, PE, Brazil., Mendonça-Junior FJB; Laboratory of Synthesis and Drug Delivery, State University of Paraíba, João Pessoa 58071-160, PB, Brazil., Damasceno BPGL; Department of Pharmacy, Center for Biological and Health Sciences, State University of Paraíba, Campina Grande 58429-600, PB, Brazil., Converti A; Department of Civil, Chemical and Environment Engineering, Pole of Chemical Engineering, University of Genoa, I-16145 Genoa, Italy., Lima ÁAN; Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
المصدر: Marine drugs [Mar Drugs] 2022 Jan 26; Vol. 20 (2). Date of Electronic Publication: 2022 Jan 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Antifungal Agents*/administration & dosage , Antifungal Agents*/chemistry , Antifungal Agents*/pharmacology , Candida*/drug effects , Chitosan*/chemistry , Thiophenes*/chemistry, Administration, Topical ; Drug Carriers/chemistry
مستخلص: In this study, films of chitosan and 2-amino-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitrile (6CN), a 2-aminothiophene derivative with great pharmacological potential, were prepared as a system for a topical formulation. 6CN-chitosan films were characterized by physicochemical analyses, such as Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electronic microscopy (SEM). Additionally, the antifungal potential of the films was evaluated in vitro against three species of Candida ( C. albicans , C. tropicalis , and C. parapsilosis ). The results of the FTIR and thermal analysis showed the incorporation of 6CN in the polymer matrix. In the diffractogram, the 6CN-chitosan films exhibited diffraction halos that were characteristic of amorphous structures, while the micrographs showed that 6CN particles were dispersed in the chitosan matrix, exhibiting pores and cracks on the film surface. In addition, the results of antifungal investigation demonstrated that 6CN-chitosan films were effective against Candida species showing potential for application as a new antifungal drug.
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معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: 2-aminothiophene derivative; antifungal activity; chitosan; films
المشرفين على المادة: 0 (Antifungal Agents)
9012-76-4 (Chitosan)
0 (Drug Carriers)
0 (2-amino-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carbonitrile)
0 (Thiophenes)
تواريخ الأحداث: Date Created: 20220224 Date Completed: 20220318 Latest Revision: 20240229
رمز التحديث: 20240229
مُعرف محوري في PubMed: PMC8878255
DOI: 10.3390/md20020103
PMID: 35200633
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md20020103