دورية أكاديمية
AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children.
العنوان: | AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children. |
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المؤلفون: | Chen YP; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China., Yuan L; Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China., Lin HR; Faculty of Medicine, Macau University of Science and Technology, Macau, 999078, China., Huang XK; Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China., Ruan JC; Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, 325027, Zhejiang, China. ruanjichen@163.com., Zhuo ZJ; Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China. zhenjianzhuo@163.com.; Laboratory Animal Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China. zhenjianzhuo@163.com. |
المصدر: | Discover. Oncology [Discov Oncol] 2021 Dec 15; Vol. 12 (1), pp. 62. Date of Electronic Publication: 2021 Dec 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [New York] : Springer, [2021]- |
مستخلص: | Introduction: Central nervous system (CNS) tumors comprise 15-20% of all malignancies occurring in childhood and adolescence. Previous researches have shown that overexpression and amplification of the AURKA gene could induce multiple human malignancies, with which the connection of CNS tumor susceptibility has not been extensively studied. Material and Methods: In this study, we assessed whether and to what extent AURKA gene single nucleotide polymorphisms (SNPs) (rs1047972 C > T, rs2273535 T > A, rs8173 G > C) were associated with CNS tumor susceptibility, based on a case-control analysis in 191 CNS tumor patients and 248 controls. We determined this correlation using odds ratios (ORs) and 95% confidence intervals (CIs). Results: AURKA gene rs8173 G > C exhibited a crucial function to CNS tumor susceptibility fall-off (GC/CC vs. GG: adjusted OR = 0.68, 95% CI = 0.46-0.998, P = 0.049). In addition, the combined effect of lowering the risk of developing CNS tumors was more pronounced in carriers with 3 protective genotypes than others (adjusted OR = 0.55, 95% CI = 0.31-0.98, P = 0.044). Further stratification analysis illustrated that the existence of rs8173 GC/CC and three protective genotypes lowered CNS tumor risk in some subgroups. Conclusions: Our research suggested that the AURKA gene rs8173 G > C could significantly reduce CNS tumor susceptibility in Chinese children. More functional experiments are needed to explore the role of the AURKA gene rs8173 G > C. (© 2021. The Author(s).) |
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معلومات مُعتمدة: | 81802346 National Natural Science Foundation of China; 2020T130132 China Postdoctoral Science Foundation |
فهرسة مساهمة: | Keywords: AURKA; CNS tumor; Chinese; Polymorphism; Risk |
تواريخ الأحداث: | Date Created: 20220224 Latest Revision: 20220226 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8777528 |
DOI: | 10.1007/s12672-021-00459-w |
PMID: | 35201446 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2730-6011 |
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DOI: | 10.1007/s12672-021-00459-w |