دورية أكاديمية
أعرض في EDS

α 1 -Acid Glycoprotein-Decorated Hyaluronic Acid Nanoparticles for Suppressing Metastasis and Overcoming Drug Resistance Breast Cancer.

التفاصيل البيبلوغرافية
العنوان: α 1 -Acid Glycoprotein-Decorated Hyaluronic Acid Nanoparticles for Suppressing Metastasis and Overcoming Drug Resistance Breast Cancer.
المؤلفون: Omar H; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; KACST-BWH/Harvard Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia., Fardous R; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; KACST-BWH/Harvard Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia., Alhindi YM; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; KACST-BWH/Harvard Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia., Aodah AH; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; Pharmaceutical Analysis Lab at King Abdulaziz City for Science and Technology (PALab), Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia., Alyami M; Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia., Alsuabeyl MS; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia., Alghamdi WM; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia., Alhasan AH; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; KACST-BWH/Harvard Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia.; National Center for Biotechnology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia.; College of Science and General Studies, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi Arabia., Almalik A; National Center for Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11564, Saudi Arabia.; KACST-BWH/Harvard Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh 11533, Saudi Arabia.
المصدر: Biomedicines [Biomedicines] 2022 Feb 09; Vol. 10 (2). Date of Electronic Publication: 2022 Feb 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Robust inflammation-suppressing nanoparticles based on α 1 -acid glycoprotein (AGP)-conjugated hyaluronic acid nanoparticles (AGP-HA NPs) were designed to regulate breast cancer cells' sensitivity to chemotherapy and to suppress tumor metastasis. The successful conjugation between AGP and HA NPs was confirmed using FTIR, zeta potential, and UV-vis spectroscopy. In vitro studies on MCF-7 cells indicated the remarkable ability of AGP-HA NPs in suppressing migratory tumor ability by 79% after 24 h. Moreover, the efficacy study showed the high capability of AGP-HA NPs in modulating MDA-MB-231 cells and restoring cell sensitivity to the chemotherapeutic drug doxorubicin (DOX). Furthermore, the finding obtained by flow cytometry and confocal spectroscopy demonstrated that AGP-HA NPs enhanced DOX uptake/retention and aided it to reach cell nucleus within 4 h of incubation. Therefore, AGP-HA NPs represent a viable and effective treatment option to strengthen the anticancer effects of chemotherapeutic agents and potentially improve patients' survival rates.
References: J Mater Chem B. 2020 Feb 14;8(6):1157-1170. (PMID: 31951231)
Cancer Res. 2005 Aug 1;65(15):6660-7. (PMID: 16061646)
Cell. 2017 Feb 9;168(4):670-691. (PMID: 28187288)
Sci Rep. 2017 Sep 5;7(1):10542. (PMID: 28874846)
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7024-9. (PMID: 9618532)
PLoS One. 2017 Sep 15;12(9):e0183662. (PMID: 28915246)
Macromol Biosci. 2013 Dec;13(12):1671-80. (PMID: 24106105)
Nat Rev Clin Oncol. 2021 May;18(5):280-296. (PMID: 33514910)
Onco Targets Ther. 2014 Jun 12;7:1015-23. (PMID: 24959088)
Biomaterials. 2013 Apr;34(13):3489-502. (PMID: 23410679)
Methods Mol Biol. 2005;294:23-9. (PMID: 15576902)
Drug Resist Updat. 2015 Jan;18:1-17. (PMID: 25554624)
J Membr Biol. 1997 Dec 1;160(3):161-75. (PMID: 9425600)
Int J Biol Macromol. 2013 Jun;57:204-12. (PMID: 23500442)
J Control Release. 2013 Dec 28;172(3):1142-50. (PMID: 24103813)
Biophys Rev. 2016 Jun;8(2):163-177. (PMID: 28510057)
Signal Transduct Target Ther. 2018 Mar 16;3:7. (PMID: 29560283)
Macromol Biosci. 2008 May 13;8(5):441-50. (PMID: 18236434)
Cancer Metastasis Rev. 1994 Jun;13(2):223-33. (PMID: 7923552)
Chem Sci. 2016 Jan 1;7(1):489-498. (PMID: 28791102)
Methods Mol Biol. 2010;596:467-88. (PMID: 19949937)
J Immunol Res. 2014;2014:149185. (PMID: 24901008)
Toxicol Res (Camb). 2018 May 23;7(5):942-950. (PMID: 30310671)
ACS Appl Mater Interfaces. 2017 Aug 16;9(32):26648-26664. (PMID: 28741923)
Eur J Cancer. 1996 Jun;32A(6):1070-81. (PMID: 8763349)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
ACS Nano. 2019 Jan 22;13(1):274-283. (PMID: 30566319)
J Drug Target. 2015;23(7-8):605-18. (PMID: 26453158)
Oncogene. 2018 Jun;37(25):3456-3470. (PMID: 29559745)
J Control Release. 2014 Nov 28;194:238-56. (PMID: 25204288)
J Biomed Sci. 2013 Dec 20;20:99. (PMID: 24358977)
Pharmacol Ther. 2007 Feb;113(2):429-41. (PMID: 17208306)
Cytokine Growth Factor Rev. 2003 Feb;14(1):25-34. (PMID: 12485617)
Int J Pharm. 2003 Jan 2;250(1):215-26. (PMID: 12480287)
Biochem Cell Biol. 2006 Dec;84(6):979-92. (PMID: 17215884)
PLoS One. 2014 Oct 09;9(10):e109980. (PMID: 25299052)
Theranostics. 2018 Jan 1;8(4):1059-1074. (PMID: 29463999)
Biochim Biophys Acta. 2000 Oct 18;1482(1-2):284-97. (PMID: 11058769)
J Leukoc Biol. 1996 Feb;59(2):280-6. (PMID: 8604001)
Cell. 2006 Nov 17;127(4):679-95. (PMID: 17110329)
فهرسة مساهمة: Keywords: breast cancer cells; hyaluronic acid (HA) nanoparticles; immune-suppressing nanoparticles; multidrug resistance (MDR); tumor metastasis; α1-acid glycoprotein (AGP)
تواريخ الأحداث: Date Created: 20220225 Latest Revision: 20220401
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8962395
DOI: 10.3390/biomedicines10020414
PMID: 35203623
قاعدة البيانات: MEDLINE
الوصف
تدمد:2227-9059
DOI:10.3390/biomedicines10020414