دورية أكاديمية
أعرض في EDS

"Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism.

التفاصيل البيبلوغرافية
العنوان: "Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism.
المؤلفون: Ivanov YD; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Malsagova KA; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Goldaeva KV; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Pleshakova TO; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Shumov ID; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Galiullin RA; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Kapustina SI; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Iourov IY; Mental Health Research Center, 117152 Moscow, Russia., Vorsanova SG; Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Taldomskaya St. 2, 125412 Moscow, Russia., Ryabtsev SV; Center for Research of Social Systems, 354340 Sochi, Russia., Popov VP; Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia., Archakov AI; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia.
المصدر: Genes [Genes (Basel)] 2022 Jan 22; Vol. 13 (2). Date of Electronic Publication: 2022 Jan 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Autistic Disorder*/genetics , Biosensing Techniques* , MicroRNAs*/genetics , Nanowires*/chemistry, Biomarkers ; Child ; Humans ; Silicon/chemistry
مستخلص: MicroRNAs (miRNAs), which represent short (20 to 22 nt) non-coding RNAs, were found to play a direct role in the development of autism in children. Herein, a highly sensitive "silicon-on-insulator"-based nanosensor (SOI-NS) has been developed for the revelation of autism-associated miRNAs. This SOI-NS comprises an array of nanowire sensor structures fabricated by complementary metal-oxide-semiconductor (CMOS)-compatible technology, gas-phase etching, and nanolithography. In our experiments described herein, we demonstrate the revelation of ASD-associated miRNAs in human plasma with the SOI-NS, whose sensor elements were sensitized with oligonucleotide probes. In order to determine the concentration sensitivity of the SOI-NS, experiments on the detection of synthetic DNA analogues of autism-associated miRNAs in purified buffer were performed. The lower limit of miRNA detection attained in our experiments amounted to 10 -17 M.
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فهرسة مساهمة: Keywords: autism; microRNA; nanosensor; nucleic acid detection
المشرفين على المادة: 0 (Biomarkers)
0 (MicroRNAs)
Z4152N8IUI (Silicon)
تواريخ الأحداث: Date Created: 20220225 Date Completed: 20220425 Latest Revision: 20220425
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8872218
DOI: 10.3390/genes13020199
PMID: 35205244
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes13020199