دورية أكاديمية
"Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism.
العنوان: | "Silicon-On-Insulator"-Based Nanosensor for the Revelation of MicroRNA Markers of Autism. |
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المؤلفون: | Ivanov YD; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Malsagova KA; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Goldaeva KV; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Pleshakova TO; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Shumov ID; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Galiullin RA; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Kapustina SI; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia., Iourov IY; Mental Health Research Center, 117152 Moscow, Russia., Vorsanova SG; Veltischev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Taldomskaya St. 2, 125412 Moscow, Russia., Ryabtsev SV; Center for Research of Social Systems, 354340 Sochi, Russia., Popov VP; Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia., Archakov AI; Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, Russia. |
المصدر: | Genes [Genes (Basel)] 2022 Jan 22; Vol. 13 (2). Date of Electronic Publication: 2022 Jan 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI |
مواضيع طبية MeSH: | Autistic Disorder*/genetics , Biosensing Techniques* , MicroRNAs*/genetics , Nanowires*/chemistry, Biomarkers ; Child ; Humans ; Silicon/chemistry |
مستخلص: | MicroRNAs (miRNAs), which represent short (20 to 22 nt) non-coding RNAs, were found to play a direct role in the development of autism in children. Herein, a highly sensitive "silicon-on-insulator"-based nanosensor (SOI-NS) has been developed for the revelation of autism-associated miRNAs. This SOI-NS comprises an array of nanowire sensor structures fabricated by complementary metal-oxide-semiconductor (CMOS)-compatible technology, gas-phase etching, and nanolithography. In our experiments described herein, we demonstrate the revelation of ASD-associated miRNAs in human plasma with the SOI-NS, whose sensor elements were sensitized with oligonucleotide probes. In order to determine the concentration sensitivity of the SOI-NS, experiments on the detection of synthetic DNA analogues of autism-associated miRNAs in purified buffer were performed. The lower limit of miRNA detection attained in our experiments amounted to 10 -17 M. |
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فهرسة مساهمة: | Keywords: autism; microRNA; nanosensor; nucleic acid detection |
المشرفين على المادة: | 0 (Biomarkers) 0 (MicroRNAs) Z4152N8IUI (Silicon) |
تواريخ الأحداث: | Date Created: 20220225 Date Completed: 20220425 Latest Revision: 20220425 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8872218 |
DOI: | 10.3390/genes13020199 |
PMID: | 35205244 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2073-4425 |
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DOI: | 10.3390/genes13020199 |