دورية أكاديمية
أعرض في EDS

Type I conventional dendritic cells relate to disease severity in virus-induced asthma exacerbations.

التفاصيل البيبلوغرافية
العنوان: Type I conventional dendritic cells relate to disease severity in virus-induced asthma exacerbations.
المؤلفون: Cameron A; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Dhariwal J; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Upton N; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK., Ranz Jimenez I; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK., Paulsen M; St. Mary's Flow Cytometry Core Facility, London, UK.; Novo Nordisk Foundation Center for Stem Cell Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wong E; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Trujillo-Torralbo MB; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Del Rosario A; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Jackson DJ; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK.; Guy's and St Thomas' NHS Trust, London, UK., Edwards MR; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Johnston SL; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK., Walton RP; National Heart and Lung Institute, London, UK.; MRC Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
مؤلفون مشاركون: MRC-GSK Strategic Alliance Consortium
المصدر: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2022 Apr; Vol. 52 (4), pp. 550-560. Date of Electronic Publication: 2022 Mar 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications, c1989-
مواضيع طبية MeSH: Asthma* , Picornaviridae Infections*, Dendritic Cells ; Humans ; Rhinovirus ; Severity of Illness Index
مستخلص: Rationale: Rhinoviruses are the major precipitant of asthma exacerbations and individuals with asthma experience more severe/prolonged rhinovirus infections. Concurrent viral infection and allergen exposure synergistically increase exacerbation risk. Although dendritic cells orchestrate immune responses to both virus and allergen, little is known about their role in viral asthma exacerbations.
Objectives: To characterize dendritic cell populations present in the lower airways, and to assess whether their numbers are altered in asthma compared to healthy subjects prior to infection and during rhinovirus-16 infection.
Methods: Moderately-severe atopic asthmatic patients and healthy controls were experimentally infected with rhinovirus-16. Bronchoalveolar lavage was collected at baseline, day 3 and day 8 post infection and dendritic cells isolated using fluorescence activated cell sorting.
Measurements and Main Results: Numbers of type I conventional dendritic cells, which cross prime CD8 + T helper cells and produce innate interferons, were significantly reduced in the lower airways of asthma patients compared to healthy controls at baseline. This reduction was associated serum IgE at baseline and with reduced numbers of CD8 + T helper cells and with increased viral replication, airway eosinophils and reduced lung function during infection. IgE receptor expression on lower airway plasmacytoid dendritic cells was significantly increased in asthma, consistent with a reduced capacity to produce innate interferons.
Conclusions: Reduced numbers of anti-viral type I conventional dendritic cells in asthma are associated with adverse outcomes during rhinovirus infection. This, with increased FcεR1α expression on lower airway plasmacytoid DCs could mediate the more permissive respiratory viral infection observed in asthma patients.
(© 2022 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: G1000758 United Kingdom MRC_ Medical Research Council; G1100238 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health
فهرسة مساهمة: Keywords: DC; atopy; rhinovirus
تواريخ الأحداث: Date Created: 20220225 Date Completed: 20220405 Latest Revision: 20230208
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9310571
DOI: 10.1111/cea.14116
PMID: 35212067
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2222
DOI:10.1111/cea.14116