دورية أكاديمية
أعرض في EDS

Dendritic Spine Density Scales with Microtubule Number in Rat Hippocampal Dendrites.

التفاصيل البيبلوغرافية
العنوان: Dendritic Spine Density Scales with Microtubule Number in Rat Hippocampal Dendrites.
المؤلفون: Harris KM; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States. Electronic address: Kharris@utexas.edu., Hubbard DD; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Kuwajima M; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Abraham WC; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Bourne JN; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Bowden JB; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Haessly A; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Mendenhall JM; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Parker PH; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Shi B; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States., Spacek J; Department of Neuroscience, Center for Learning and Memory, University of Texas at Austin, Austin, TX, United States.
المصدر: Neuroscience [Neuroscience] 2022 May 01; Vol. 489, pp. 84-97. Date of Electronic Publication: 2022 Feb 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Dendrites*/physiology , Dendritic Spines*, Animals ; Hippocampus ; Microtubules ; Pyramidal Cells/physiology ; Rats ; Synapses/physiology
مستخلص: Microtubules deliver essential resources to and from synapses. Three-dimensional reconstructions in rat hippocampus reveal a sampling bias regarding spine density that needs to be controlled for dendrite caliber and resource delivery based on microtubule number. The strength of this relationship varies across dendritic arbors, as illustrated for area CA1 and dentate gyrus. In both regions, proximal dendrites had more microtubules than distal dendrites. For CA1 pyramidal cells, spine density was greater on thicker than thinner dendrites in stratum radiatum, or on the more uniformly thin terminal dendrites in stratum lacunosum moleculare. In contrast, spine density was constant across the cone shaped arbor of tapering dendrites from dentate granule cells. These differences suggest that thicker dendrites supply microtubules to subsequent dendritic branches and local dendritic spines, whereas microtubules in thinner dendrites need only provide resources to local spines. Most microtubules ran parallel to dendrite length and associated with long, presumably stable mitochondria, which occasionally branched into lateral dendritic branches. Short, presumably mobile, mitochondria were tethered to microtubules that bent and appeared to direct them into a thin lateral branch. Prior work showed that dendritic segments with the same number of microtubules had elevated resources in subregions of their dendritic shafts where spine synapses had enlarged, and spine clusters had formed. Thus, additional microtubules were not required for redistribution of resources locally to growing spines or synapses. These results provide new understanding about the potential for microtubules to regulate resource delivery to and from dendritic branches and locally among dendritic spines.
(Copyright © 2022 IBRO. Published by Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 NS074644 United States NS NINDS NIH HHS; R56 MH095980 United States MH NIMH NIH HHS; R01 MH104319 United States MH NIMH NIH HHS; R01 NS021184 United States NS NINDS NIH HHS; R37 NS021184 United States NS NINDS NIH HHS; R01 MH095980 United States MH NIMH NIH HHS; R01 NS033574 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: 3D-reconstruction; microtubules; spine density; synapses; ultrastructure
تواريخ الأحداث: Date Created: 20220226 Date Completed: 20220426 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC9038701
DOI: 10.1016/j.neuroscience.2022.02.021
PMID: 35218884
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2022.02.021