دورية أكاديمية
Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism.
| العنوان: | Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism. |
|---|---|
| المؤلفون: | Yakupova EI; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia.; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino 142290, Russia., Maleev GV; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia., Krivtsov AV; Center for Pediatric Cancer Therapeutics, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Plotnikov EY; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119234, Russia.; V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Moscow 117997, Russia. |
| المصدر: | Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2022 Jun; Vol. 247 (11), pp. 958-971. Date of Electronic Publication: 2022 Feb 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Lausanne, Switzerland : Frontiers Media S.A. Original Publication: Maywood, NJ : The Society, c2001- |
| مواضيع طبية MeSH: | Cell Polarity* , Macrophage Activation*, Humans ; Hypoxia/metabolism ; Ischemia/metabolism ; Macrophages/metabolism ; Reperfusion |
| مستخلص: | Macrophages, the key cells of innate immunity, possess wide phenotypical and functional heterogeneity. In vitro studies showed that microenvironment signals could induce the so-called polarization of macrophages into two phenotypes: classically activated macrophages (M1) or alternatively activated macrophages (M2). Functionally, they are considered as proinflammatory and anti-inflammatory/pro-regenerative, respectively. However, in vivo studies into macrophage states revealed a continuum of phenotypes from M1 to M2 state instead of the clearly distinguished extreme phenotypes. An important role in determining the type of polarization of macrophages is played by energy metabolism, including the activity of oxidative phosphorylation. In this regard, hypoxia and ischemia that affect cellular energetics can modulate macrophage polarization. Here, we overview the data on macrophage polarization during metabolic shift-associated pathologies including ischemia and ischemia/reperfusion in various organs and discuss the role of energy metabolism potentially triggering the macrophage polarization. |
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| فهرسة مساهمة: | Keywords: M1–M2 macrophage polarization; Macrophages; energy metabolism; hypoxia; ischemia; metabolism |
| تواريخ الأحداث: | Date Created: 20220228 Date Completed: 20220610 Latest Revision: 20221202 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9189569 |
| DOI: | 10.1177/15353702221080130 |
| PMID: | 35220781 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1535-3699 |
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| DOI: | 10.1177/15353702221080130 |