دورية أكاديمية
أعرض في EDS

Occludin Promotes Adhesion of CD8 + T Cells and Melanocytes in Vitiligo via the HIF-1 α Signaling Pathway.

التفاصيل البيبلوغرافية
العنوان: Occludin Promotes Adhesion of CD8 + T Cells and Melanocytes in Vitiligo via the HIF-1 α Signaling Pathway.
المؤلفون: Zou P; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Xiao Y; Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, China.; Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, China., Deng Q; Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Shi Y; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., You R; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Pi Z; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Liu J; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Zhan Y; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Zeng Q; Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, China., Zeng Z; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China., Xiao R; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan Key Laboratory of Medical Epigenetics, China.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Feb 16; Vol. 2022, pp. 6732972. Date of Electronic Publication: 2022 Feb 16 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: CD8-Positive T-Lymphocytes/*pathology , Melanocytes/*pathology , Occludin/*metabolism , Vitiligo/*pathology, CD8-Positive T-Lymphocytes/metabolism ; Cell Adhesion ; Fibroblasts/metabolism ; Gene Expression Regulation ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Melanocytes/metabolism ; Occludin/genetics ; Oxidative Stress ; Signal Transduction ; Skin/pathology ; Vitiligo/genetics ; Vitiligo/metabolism
مستخلص: Loss of melanocytes induced by activated CD8 + T cells is the pathological hallmark of vitiligo. Melanocyte-specific CD8 + T cells are recruited to the skin via chemokines, thereby releasing perforin, granzyme, and other cytotoxic substances that destroy the melanocytes. However, the mechanism of CD8 + T cells to adhere to melanocytes is unknown. Previous transcriptome sequencing results published by our group showed that the occluding ( OCLN) gene was significantly upregulated in CD8 + T cells from skin lesions of vitiligo. Occludin is a crucial component of the tight junction between cells; in cells without tight junction, occludin mediates the adhesion of two cells in the form of a self-ligand. This study demonstrated that OCLN gene expression was elevated in the CD8 + T cells of vitiligo patients, and occludin mediates the adherence of CD8 + T cells to melanocytes. Besides, pathological changes in vitiligo skin lesions reveal that CD8 + T cells continuously persist in the skin lesions, which is related to the persistence of the disease. In this regard, we found that fibroblasts from vitiligo patients significantly express occludin, which may participate in the continuous retention of CD8 + T cells in the skin lesions. The pathogenesis of vitiligo is closely related to oxidative stress, and our data suggest that overexpression of hypoxia-inducible factor-1 α (HIF-1 α ) increases the expression of occludin. Besides, ChIP-qPCR of CD8 + T cells revealed that HIF-1 α directly binds to the OCLN promoter. Thus, occludin upregulation promotes the adhesion of CD8 + T cells and melanocytes via the HIF-1 α signaling pathway. Our study results suggested a critical role for OCLN in the occurrence, progression, and maintenance of vitiligo. Therefore, inhibiting the expression of OCLN gene may be a potential targeted treatment strategy.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article.
(Copyright © 2022 Puyu Zou et al.)
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المشرفين على المادة: 0 (HIF1A protein, human)
0 (Hypoxia-Inducible Factor 1, alpha Subunit)
0 (OCLN protein, human)
0 (Occludin)
تواريخ الأحداث: Date Created: 20220228 Date Completed: 20220317 Latest Revision: 20220317
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8865978
DOI: 10.1155/2022/6732972
PMID: 35222802
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2022/6732972