دورية أكاديمية
Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization.
العنوان: | Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization. |
---|---|
المؤلفون: | Bellefroid M; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Rodari A; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Galais M; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Krijger PHL; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584, CT, The Netherlands., Tjalsma SJD; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584, CT, The Netherlands., Nestola L; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Plant E; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Vos ESM; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584, CT, The Netherlands., Cristinelli S; Institute of Microbiology, Lausanne University Hospital, University of Lausanne, Lausanne 1011, Switzerland., Van Driessche B; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Vanhulle C; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Ait-Ammar A; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Burny A; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium., Ciuffi A; Institute of Microbiology, Lausanne University Hospital, University of Lausanne, Lausanne 1011, Switzerland., de Laat W; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584, CT, The Netherlands., Van Lint C; Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium. |
المصدر: | Nucleic acids research [Nucleic Acids Res] 2022 Apr 08; Vol. 50 (6), pp. 3190-3202. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 1992- : Oxford : Oxford University Press Original Publication: London, Information Retrieval ltd. |
مواضيع طبية MeSH: | Leukemia Virus, Bovine*/genetics , Leukemia Virus, Bovine*/metabolism , Virus Latency*, CCCTC-Binding Factor/metabolism ; Chromatin ; Promoter Regions, Genetic ; Terminal Repeat Sequences/genetics |
مستخلص: | Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the regulation of BLV transcriptional activities and in the deregulation of the three-dimensional (3D) chromatin architecture surrounding the BLV integration site. We demonstrated the in vivo recruitment of CTCF to three conserved CTCF binding motifs along the provirus. Next, we showed that CTCF localized to regions of transitions in the histone modifications profile along the BLV genome and that it is implicated in the repression of the 5'Long Terminal Repeat (LTR) promoter activity, thereby contributing to viral latency, while favoring the 3'LTR promoter activity. Finally, we demonstrated that BLV integration deregulated the host cellular 3D chromatin organization through the formation of viral/host chromatin loops. Altogether, our results highlight CTCF as a new critical effector of BLV transcriptional regulation and BLV-induced physiopathology. (© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.) |
References: | Cell. 2009 Jun 26;137(7):1194-211. (PMID: 19563753) Nature. 2011 Nov 3;479(7371):74-9. (PMID: 21964334) J Virol. 1998 Jul;72(7):5526-34. (PMID: 9621009) Bioinformatics. 2018 Jul 15;34(14):2483-2484. (PMID: 29514181) Retrovirology. 2016 May 03;13(1):33. (PMID: 27141823) J Biol Chem. 2010 Jun 18;285(25):19434-49. (PMID: 20413592) Viruses. 2020 Sep 25;12(10):. (PMID: 32992917) J Virol. 1998 Jul;72(7):5994-6003. (PMID: 9621062) Methods. 2020 Jan 1;170:17-32. (PMID: 31351925) Nat Commun. 2017 May 23;8:15264. (PMID: 28534499) Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5. (PMID: 27079975) Bioinformatics. 2011 Apr 1;27(7):1017-8. (PMID: 21330290) AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1787-95. (PMID: 11080828) Annu Rev Genomics Hum Genet. 2016 Aug 31;17:17-43. (PMID: 27089971) Nature. 2016 Jan 7;529(7584):110-4. (PMID: 26700815) Retrovirology. 2007 Jul 23;4:51. (PMID: 17645797) Nat Commun. 2019 Apr 4;10(1):1535. (PMID: 30948729) Nat Protoc. 2012 Sep;7(9):1728-40. (PMID: 22936215) Nucleic Acids Res. 2018 Sep 6;46(15):e91. (PMID: 29800273) PLoS Pathog. 2011 Aug;7(8):e1002140. (PMID: 21876668) Nat Rev Mol Cell Biol. 2016 Dec;17(12):771-782. (PMID: 27826147) J Virol. 2004 Dec;78(24):13848-64. (PMID: 15564493) Mol Cell. 2017 Apr 6;66(1):102-116.e7. (PMID: 28388437) Nucleic Acids Res. 1994 Nov 25;22(23):4872-5. (PMID: 7800474) J Virol. 2002 May;76(10):5034-42. (PMID: 11967319) Oncogene. 2003 May 15;22(19):2882-96. (PMID: 12771939) Nucleic Acids Res. 2011 Dec;39(22):9559-73. (PMID: 21890901) Cell Syst. 2019 May 22;8(5):446-455.e8. (PMID: 31078526) Nucleic Acids Res. 2018 Jan 4;46(D1):D1284. (PMID: 29161433) J Virol. 1989 May;63(5):2099-107. (PMID: 2539506) J Biol Chem. 2019 Jan 18;294(3):861-873. (PMID: 30459231) Virology. 1992 Aug;189(2):775-7. (PMID: 1322602) Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2306-11. (PMID: 23345446) J Biol Chem. 2004 Aug 13;279(33):35025-36. (PMID: 15163662) PLoS Pathog. 2013;9(10):e1003687. (PMID: 24098130) Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6456-65. (PMID: 26499245) Front Biosci (Schol Ed). 2009 Jun 01;1(1):154-63. (PMID: 19482691) Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3054-9. (PMID: 26929370) Philos Trans R Soc Lond B Biol Sci. 2013 May 06;368(1620):20120369. (PMID: 23650640) J Biol Chem. 2002 Mar 15;277(11):8775-89. (PMID: 11741930) Mol Cell. 2015 Nov 19;60(4):676-84. (PMID: 26527277) Cell. 2001 Aug 10;106(3):309-18. (PMID: 11509180) Oncogene. 2003 Mar 13;22(10):1486-90. (PMID: 12629511) Essays Biochem. 2019 Apr 23;63(1):157-165. (PMID: 30940740) Science. 2016 Mar 25;351(6280):1454-1458. (PMID: 26940867) J Virol. 1985 Jun;54(3):899-901. (PMID: 2987544) Cell. 2017 May 18;169(5):930-944.e22. (PMID: 28525758) J Virol. 2020 Jan 6;94(2):. (PMID: 31666380) Proc Natl Acad Sci U S A. 1988 Dec;85(23):9263-7. (PMID: 2848258) Annu Rev Virol. 2019 Sep 29;6(1):365-385. (PMID: 31283437) Int J Mol Sci. 2020 Nov 25;21(23):. (PMID: 33255744) PLoS Pathog. 2011 Jul;7(7):e1002180. (PMID: 21829357) Nucleic Acids Res. 2000 Apr 15;28(8):1707-13. (PMID: 10734189) Front Microbiol. 2013 Nov 08;4:328. (PMID: 24265629) Curr Opin Virol. 2017 Oct;26:125-131. (PMID: 28822906) Retrovirology. 2019 Dec 21;16(1):44. (PMID: 31864373) J Virol. 1999 Feb;73(2):1054-65. (PMID: 9882306) Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286) EMBO J. 1987 Nov;6(11):3385-9. (PMID: 2828028) Retrovirology. 2007 Mar 16;4:18. (PMID: 17362524) J Biol Chem. 2007 Jul 20;282(29):20854-67. (PMID: 17526487) Sci Rep. 2016 Aug 22;6:31125. (PMID: 27545598) Elife. 2018 Jun 26;7:. (PMID: 29941091) Wellcome Open Res. 2018 Aug 24;3:105. (PMID: 30607369) PLoS Pathog. 2021 May 21;17(5):e1009577. (PMID: 34019588) Genome Res. 2009 Jan;19(1):24-32. (PMID: 19056695) PLoS Pathog. 2020 May 14;16(5):e1008502. (PMID: 32407379) Nat Commun. 2019 May 30;10(1):2367. (PMID: 31147539) J Virol. 1996 Mar;70(3):1990-9. (PMID: 8627725) J Dairy Sci. 2013 Mar;96(3):1591-7. (PMID: 23332856) Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3077-82. (PMID: 22308400) Genes Dev. 2006 Sep 1;20(17):2349-54. (PMID: 16951251) Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943) Dev Cell. 2011 Sep 13;21(3):559-74. (PMID: 21871842) J Biol Chem. 2000 Jan 7;275(1):697-704. (PMID: 10617669) Transcription. 2015;6(5):79-90. (PMID: 26399478) Mol Cell Biol. 2007 Mar;27(5):1631-48. (PMID: 17210645) J Cell Biol. 2017 Nov 6;216(11):3441-3452. (PMID: 28855250) PLoS Pathog. 2016 Apr 28;12(4):e1005588. (PMID: 27123579) Viruses. 2015 Jul 06;7(7):3574-85. (PMID: 26154016) |
المشرفين على المادة: | 0 (CCCTC-Binding Factor) 0 (Chromatin) |
تواريخ الأحداث: | Date Created: 20220302 Date Completed: 20220415 Latest Revision: 20220504 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8989512 |
DOI: | 10.1093/nar/gkac107 |
PMID: | 35234910 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1362-4962 |
---|---|
DOI: | 10.1093/nar/gkac107 |