دورية أكاديمية
أعرض في EDS

Effect of PUVA and NB-UVB Therapy on the Skin Cytokine Profile in Patients with Mycosis Fungoides.

التفاصيل البيبلوغرافية
العنوان: Effect of PUVA and NB-UVB Therapy on the Skin Cytokine Profile in Patients with Mycosis Fungoides.
المؤلفون: Karamova AE; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia.; RSDC (Russian Society of Dermatovenereologists and Cosmetologists), Moscow, Russia., Verbenko DA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia., Vorontsova AA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia., Zhilova MB; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia.; RSDC (Russian Society of Dermatovenereologists and Cosmetologists), Moscow, Russia., Nikonorov AA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia., Gatiatulina ER; All-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, 117216 Moscow, Russia., Znamenskaya LF; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia., Kubanov AA; State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, Bldg 6, 107076 Moscow, Russia.; RSDC (Russian Society of Dermatovenereologists and Cosmetologists), Moscow, Russia.
المصدر: Journal of oncology [J Oncol] 2022 Feb 21; Vol. 2022, pp. 3149293. Date of Electronic Publication: 2022 Feb 21 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101496537 Publication Model: eCollection Cited Medium: Print ISSN: 1687-8450 (Print) Linking ISSN: 16878450 NLM ISO Abbreviation: J Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cairo : Hindawi Publishing Corporation
مستخلص: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. The aim of the present study was to produce up-to-date information on different phototherapy approaches on skin cytokines in patients with MF.
Methods: A total of 27 patients with mycosis fungoides were treated with phototherapy: NB-UVB (narrow-band ultraviolet B therapy) (10 patients) and PUVA (long-wavelength ultraviolet radiation of spectrum A with the use of skin-photosensitizing furocoumarins) therapy (17 patients). Evaluation of the effectiveness of treatment was carried out using BSA (body surface area) and the modified assessment of the severity of the skin lesions scale (mSWAT) used to quantify tumor mass in cutaneous T-cell lymphomas. Average numbers of procedures were 30.2 and 27.8 in the NB-UVB and PUVA groups, respectively. The median total dose of NB-UVB irradiation was 19.9 J/cm 2 and PUVA therapy was 104.0 J/cm 2 . The overall response to therapy including complete and partial remission was 74.9% in the total group; 70% in the NB-UVB group, and 77.7% in the PUVA therapy group. In the obtained biopsies from lesions, surrounding tissue before treatment and skin samples of four healthy volunteers, the concentration of the IL-1 β , IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN- γ , sCD40L, and TNF- α cytokines was studied. An increase in IL-4 and TNF- α levels was shown in the lesional skin of patients compared to the skin of healthy controls. After the treatment, positive correlations of mSWAT with the levels of IL22, IL33, and TNF- α in the tumor tissue were found. The levels of IL10 and IFN- γ after PUVA treatment were increased in comparison to baseline. There was no difference in cytokine levels before/after NB-UVB therapy.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2022 Arfenya E. Karamova et al.)
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تواريخ الأحداث: Date Created: 20220303 Latest Revision: 20220502
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8885178
DOI: 10.1155/2022/3149293
PMID: 35237320
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-8450
DOI:10.1155/2022/3149293