دورية أكاديمية
Is Amniocentesis after CVS Risky?
| العنوان: | Is Amniocentesis after CVS Risky? |
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| المؤلفون: | Cagino K; Department of Obstetrics and Gynecology, New York Presbyterian Weill Cornell Medical Center, New York., Chasen ST; Department of Obstetrics and Gynecology, New York Presbyterian Weill Cornell Medical Center, New York. |
| المصدر: | American journal of perinatology [Am J Perinatol] 2024 May; Vol. 41 (7), pp. 876-878. Date of Electronic Publication: 2022 Mar 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme-Stratton Country of Publication: United States NLM ID: 8405212 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8785 (Electronic) Linking ISSN: 07351631 NLM ISO Abbreviation: Am J Perinatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Thieme-Stratton, 1983- |
| مواضيع طبية MeSH: | Amniocentesis*/adverse effects , Amniocentesis*/statistics & numerical data , Chorionic Villi Sampling*/adverse effects , Chorionic Villi Sampling*/statistics & numerical data , Mosaicism*, Humans ; Female ; Pregnancy ; Retrospective Studies ; Adult ; Case-Control Studies ; Pregnancy Outcome |
| مستخلص: | Objective: Approximately, 2% of women who undergo chorionic villi sampling (CVS) will subsequently undergo amniocentesis due to placental mosaicism or sampling/laboratory issues. Our objective was to compare obstetric outcomes in women who underwent both procedures with those who had CVS alone. Study Design: Retrospective case-control study of patients with singleton pregnancies undergoing invasive testing from 2010 to 2020 was performed. All women who underwent CVS followed by amniocentesis were compared with a control group who underwent CVS alone matched (2:1) for age and year of pregnancy. Women with pregnancy loss at <16 weeks were excluded from the control group. Pregnancies terminated for genetic abnormalities were excluded. Obstetric outcomes were compared between cases and controls. Student t -test and Fisher's exact test were used for statistical comparison. Results: During the study period 2,539 women underwent CVS, and 66 (2.6%) subsequently underwent amniocentesis. The 66 cases were compared with 132 age-matched controls who underwent CVS alone. Mean maternal age was 36.8 ± 3.4 years, and 43% of women were nulliparous. Amniocentesis was performed due to sampling or laboratory issues in 33% of cases, placental mosaicism in 44%, and further diagnostic testing in 23%. There were no pregnancy losses or stillbirths in either group. Those who had two invasive procedures delivered at similar gestational ages and birthweights and did not have higher rates of adverse outcomes compared with those who underwent CVS alone. Conclusion: Patients considering CVS who are concerned about the possibility that a second invasive procedure could be required should be reassured that this does not appear to be associated with higher rates of adverse outcomes. Due to study size, we cannot exclude the possibility of small differences in uncommon outcomes, such as pregnancy loss or stillbirth. Key Points: · Amniocentesis may be recommended after CVS due to mosaicism, sampling issues, or further testing.. · Amniocentesis after CVS is not associated with pregnancy loss or other adverse outcomes compared.. · Patients who have both CVS and amniocentesis deliver at similar gestational ages and birthweights.. Competing Interests: None declared. (Thieme. All rights reserved.) |
| References: | Ultrasound Obstet Gynecol. 2019 Oct;54(4):442-451. (PMID: 31124209) J Perinat Med. 2019 Oct 25;47(8):811-816. (PMID: 31503543) Fetal Diagn Ther. 2019;46(3):149-152. (PMID: 30352439) Ultrasound Obstet Gynecol. 2017 May;49(5):599-606. (PMID: 27255564) Obstet Gynecol. 2005 Mar;105(3):587-92. (PMID: 15738029) Prenat Diagn. 2015 Nov;35(11):1117-27. (PMID: 26213308) Obstet Gynecol. 2006 Jan;107(1):128-35. (PMID: 16394050) Obstet Gynecol. 2014 Jul;124(1):16-22. (PMID: 24901276) |
| معلومات مُعتمدة: | UL1 TR002384 United States TR NCATS NIH HHS |
| تواريخ الأحداث: | Date Created: 20220303 Date Completed: 20240424 Latest Revision: 20240729 |
| رمز التحديث: | 20240729 |
| مُعرف محوري في PubMed: | PMC11132116 |
| DOI: | 10.1055/a-1787-6785 |
| PMID: | 35240697 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-8785 |
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| DOI: | 10.1055/a-1787-6785 |