دورية أكاديمية
Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma.
| العنوان: | Glutamate-cysteine ligase catalytic and its modifier function as novel immunotargets in gastric adenocarcinoma. |
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| المؤلفون: | Da D; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Pan Z; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Zeng L; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Dang Y; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Dang C; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Huang Y; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Shi D; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China., Li H; Department of Oncology, Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, 204 Donggang West Road, Lanzhou, Gansu 730000, PR China. Electronic address: lihongling1969@126.com. |
| المصدر: | Asian journal of surgery [Asian J Surg] 2023 Jan; Vol. 46 (1), pp. 143-149. Date of Electronic Publication: 2022 Mar 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8900600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0219-3108 (Electronic) Linking ISSN: 10159584 NLM ISO Abbreviation: Asian J Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Amsterdam] : Elsevier Original Publication: [Hong Kong] : The Association, [1988- |
| مواضيع طبية MeSH: | Adenocarcinoma*/genetics , Adenocarcinoma*/metabolism , Glutamate-Cysteine Ligase*/genetics , Glutamate-Cysteine Ligase*/metabolism , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism, Humans ; Glutathione |
| مستخلص: | Objectives: To determine the expression and function of glutamate-cysteine ligase catalytic (GCLC) and glutamate-cysteine ligase catalytic modifier (GCLM) in gastric adenocarcinoma. Methods: Bioinformatics was used to analyze the expression of GCLC and GCLM. We download and analyzed the expression of gastric adenocarcinoma patients from TCGA database. Moreover, the method of immunochemistry was used to verify the expression of GCLC and GCLM in gastric adenocarcinoma. Results: At first, the expression of GCLC and GCLM in gastric adenocarcinoma tissues were both significantly higher compared with normal tissues analyzed via TCGA database. Then, gastric adenocarcinoma tissues were collected and performed with immunochemistry. The gastric adenocarcinoma with positive staining for GCLC and GCLM was 77% and 80%, respectively, which was significantly higher compared with adjacent normal tissues (9% and 11%, respectively). Conclusions: The disordered expression of GCLC and GCLM in gastric adenocarcinoma suggested that these factors may induce tumorigenesis and may be a novel target for diagnosis and treatment of gastric adenocarcinoma. Competing Interests: Declaration of competing interest All authors declare that they have no competing interests in this study. (Copyright © 2022 Asian Surgical Association and Taiwan Robotic Surgery Association. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: GCLC; GCLM; Gastric adenocarcinoma; Immunohistochemistry |
| المشرفين على المادة: | EC 6.3.2.2 (Glutamate-Cysteine Ligase) GAN16C9B8O (Glutathione) EC 6.3.2.2 (GCLC protein, human) EC 6.3.2.2 (GCLM protein, human) |
| تواريخ الأحداث: | Date Created: 20220304 Date Completed: 20230105 Latest Revision: 20230105 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/j.asjsur.2022.02.005 |
| PMID: | 35241341 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 0219-3108 |
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| DOI: | 10.1016/j.asjsur.2022.02.005 |