دورية أكاديمية
أعرض في EDS

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling.

التفاصيل البيبلوغرافية
العنوان: Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling.
المؤلفون: Agliano F; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030 USA., Karginov TA; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030 USA., Ménoret A; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030 USA., Provatas A; Department of Chemistry, University of Connecticut, Storrs, CT 06269 USA., Vella AT; Department of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030 USA.
المصدر: IScience [iScience] 2022 Feb 15; Vol. 25 (3), pp. 103932. Date of Electronic Publication: 2022 Feb 15 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector transition but also effector T cells themselves. Although aerobic glycolysis is a hallmark of activated T cells, CD8 + T cells exposed to NAM displayed enhanced glycolysis, yet producing significantly less IFNγ. Mechanistically, NAM reduced mTORC1 activity independently of NAD + metabolism, decreasing IFNγ translation and regulating T cell transcriptional factors critical to effector/memory fate. Finally, the role of NAM in a biomedically relevant model of lung injury was tested. Specifically, a NAM-supplemented diet reduced systemic IL-2, antigen-specific T cell clonal expansion, and effector function after inhalation of Staphylococcus aureus enterotoxin A. These findings identify NAM as a potential therapeutic supplement that uncouples glycolysis from effector cytokine production and may be a powerful treatment for diseases associated with T cell hyperactivation.
Competing Interests: The authors declare no competing financial interests.
(© 2022 The Author(s).)
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فهرسة مساهمة: Keywords: Biological sciences; Immunology; Molecular biology
تواريخ الأحداث: Date Created: 20220304 Latest Revision: 20220305
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8886054
DOI: 10.1016/j.isci.2022.103932
PMID: 35243268
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2022.103932