دورية أكاديمية
أعرض في EDS

Topical administration of tacrolimus and corticosteroids in tapering doses is effective in preventing immune rejection in high-risk keratoplasty: a 5-year follow-up study.

التفاصيل البيبلوغرافية
العنوان: Topical administration of tacrolimus and corticosteroids in tapering doses is effective in preventing immune rejection in high-risk keratoplasty: a 5-year follow-up study.
المؤلفون: Qi X; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Wang L; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Zhang X; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Liu M; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Gao H; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Hospital of Shandong First Medical University, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China. gaohua100@126.com.; Shandong Eye Hospital, 372 Jingsi Road, 250021, Jinan, China. gaohua100@126.com.
المصدر: BMC ophthalmology [BMC Ophthalmol] 2022 Mar 04; Vol. 22 (1), pp. 101. Date of Electronic Publication: 2022 Mar 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Corneal Transplantation* , Tacrolimus*/pharmacology , Tacrolimus*/therapeutic use, Administration, Topical ; Adrenal Cortex Hormones ; Cyclosporine/therapeutic use ; Follow-Up Studies ; Graft Rejection/prevention & control ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Keratoplasty, Penetrating
مستخلص: Background: To evaluate the efficacy of the topical administration of immunosuppressants and corticosteroids in tapering doses in the management of patients with high-risk keratoplasty.
Methods: One hundred and six patients treated with topical immunosuppressants (50 eyes in the FK506 group and 56 eyes in the CsA group) and corticosteroid eye drops in tapering doses were enrolled in the study. The rates of rejection episodes, irreversible rejection, graft survival, and related influential factors were evaluated.
Results: The mean follow-up period was 48.1 ± 7.9 months (range, 36-60 months). The rates of rejection episodes and irreversible rejection were 14.0% and 6.00% in the FK506 group and 37.5% and 7.1% in the CsA group, respectively. Kaplan-Meier survival analysis demonstrated a significantly higher graft survival rate in the FK506 group (81.6%±5.3%, 71.1%±6.3%) compared with that in the CsA group (71.1%±6.3%, 57.5%±7.5%) at 3 and 5 years after surgery (P = 0.006). Multivariate logistic regression revealed that preoperative risk score ≥ 3 (P = 0.016) and endothelial immune rejection (P = 0.033) were risk factors associated with graft survival.
Conclusions: Topical administration of tacrolimus and corticosteroids in tapering doses is effective in decreasing the incidence of immune rejection in high-risk keratoplasty. Careful instruction of patients on the reasonable use of topical tacrolimus is critical to avoid immune rejection induced by sudden discontinuation of medication.
(© 2022. The Author(s).)
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معلومات مُعتمدة: 81870639 National Natural Science Foundation of China; 8190034317 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Corticosteroids; Cyclosporine; Immune rejection; Keratoplasty; Tacrolimus
المشرفين على المادة: 0 (Adrenal Cortex Hormones)
0 (Immunosuppressive Agents)
83HN0GTJ6D (Cyclosporine)
WM0HAQ4WNM (Tacrolimus)
تواريخ الأحداث: Date Created: 20220305 Date Completed: 20220308 Latest Revision: 20220311
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8896080
DOI: 10.1186/s12886-022-02318-w
PMID: 35246084
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2415
DOI:10.1186/s12886-022-02318-w