دورية أكاديمية

Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex.

التفاصيل البيبلوغرافية
العنوان: Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex.
المؤلفون: Johnson C; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Kretsge LN; The Graduate Program for Neuroscience, Boston University, Boston, MA, USA.; Neurophotonics Center, Boston University, Boston, MA, USA., Yen WW; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Sriram B; Praxis Precision Medicines, Inc., Boston, MA, USA., O'Connor A; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Liu RS; MS in Statistical Practice Program, Boston University, Boston, MA, USA., Jimenez JC; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Phadke RA; Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, MA, USA., Wingfield KK; Neurophotonics Center, Boston University, Boston, MA, USA.; Department of Pharmacology and Experimental Therapeutics, Boston University, Boston, MA, USA., Yeung C; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Jinadasa TJ; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Nguyen TPH; Department of Biomedical Engineering, Boston University, Boston, MA, USA., Cho ES; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Fuchs E; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Spevack ED; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Velasco BE; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Hausmann FS; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Fournier LA; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA., Brack A; Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, MA, USA., Melzer S; Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Cruz-Martín A; Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA. martini.cruz@gmail.com.; Neurophotonics Center, Boston University, Boston, MA, USA. martini.cruz@gmail.com.; Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, MA, USA. martini.cruz@gmail.com.; Center for Systems Neuroscience, Boston University, Boston, MA, USA. martini.cruz@gmail.com.; The Center for Network Systems Biology, Boston University, Boston, MA, USA. martini.cruz@gmail.com.
المصدر: Molecular psychiatry [Mol Psychiatry] 2022 May; Vol. 27 (5), pp. 2602-2618. Date of Electronic Publication: 2022 Mar 04.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
مواضيع طبية MeSH: Gyrus Cinguli*/metabolism , Vasoactive Intestinal Peptide*/metabolism, Animals ; Interneurons/metabolism ; Mice ; Neurons/metabolism ; Pyramidal Cells/metabolism
مستخلص: A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional and imaging studies revealed its importance in the encoding of anxiety-related and social stimuli, but it is unknown how microcircuits within the ACC encode these distinct stimuli. One type of inhibitory interneuron, which is positive for vasoactive intestinal peptide (VIP), is known to modulate the activity of pyramidal cells in local microcircuits, but it is unknown whether VIP cells in the ACC (VIP ACC ) are engaged by particular contexts or stimuli. Additionally, recent studies demonstrated that neuronal representations in other cortical areas can change over time at the level of the individual neuron. However, it is not known whether stimulus representations in the ACC remain stable over time. Using in vivo Ca 2+ imaging and miniscopes in freely behaving mice to monitor neuronal activity with cellular resolution, we identified individual VIP ACC that preferentially activated to distinct stimuli across diverse tasks. Importantly, although the population-level activity of the VIP ACC remained stable across trials, the stimulus-selectivity of individual interneurons changed rapidly. These findings demonstrate marked functional heterogeneity and instability within interneuron populations in the ACC. This work contributes to our understanding of how the cortex encodes information across diverse contexts and provides insight into the complexity of neural processes involved in anxiety and social behavior.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: R01 MH129732 United States MH NIMH NIH HHS; T32 GM008541 United States GM NIGMS NIH HHS
المشرفين على المادة: 37221-79-7 (Vasoactive Intestinal Peptide)
تواريخ الأحداث: Date Created: 20220305 Date Completed: 20220530 Latest Revision: 20240528
رمز التحديث: 20240528
مُعرف محوري في PubMed: PMC11128891
DOI: 10.1038/s41380-022-01485-y
PMID: 35246635
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5578
DOI:10.1038/s41380-022-01485-y