دورية أكاديمية
Salvia hispanica L. seeds extract alleviate encephalopathy in streptozotocin-induced diabetes in rats: role of oxidative stress, neurotransmitters, DNA and histological indices.
| العنوان: | Salvia hispanica L. seeds extract alleviate encephalopathy in streptozotocin-induced diabetes in rats: role of oxidative stress, neurotransmitters, DNA and histological indices. |
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| المؤلفون: | El-Feky AM; Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt., Elbatanony MM; Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt., Aboul Naser AF; Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt., Younis EA; Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt., Hamed MA; Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt. |
| المصدر: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2022 Jul; Vol. 27 (5), pp. 427-440. Date of Electronic Publication: 2022 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tayor & Francis Country of Publication: England NLM ID: 9606000 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5804 (Electronic) Linking ISSN: 1354750X NLM ISO Abbreviation: Biomarkers Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Tayor & Francis Original Publication: London : Taylor & Francis, c1996- |
| مواضيع طبية MeSH: | Brain Diseases*/drug therapy , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Experimental*/pathology , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Salvia hispanica*/chemistry, Acetylcholinesterase ; Animals ; DNA ; Neurotransmitter Agents ; Oxidative Stress ; Rats ; Seeds/chemistry ; Streptozocin |
| مستخلص: | Context: Diabetes mellitus (DM) is a metabolic disorder and may lead to cognitive dysfunctions. Objective: The aim of this work is to evaluate the potency of Salvia hispanica L. seeds ( S. hispanica L.) (chia seeds) petroleum ether extract in attenuating brain complications associated with streptozotocin (STZ) induced diabetes in rats. Materials and Methods: Phytochemical composition of the seeds extract, macro and micro elements, vitamins, protein, carbohydrate and caloric values were estimated. Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg body weight (b.wt)). Glibenclamide as a reference drug was also evaluated. The biochemical evaluation was done by measuring levels of glucose, insulin, α- amylase, glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), dopamine (DA), serotonin (5-HD), noradrenaline (NE), acetylcholinesterase (AchE), tumour necrosis factor-α (TNF-α), DNA fragmentation pattern and the histopathological profile of the brain hippocampus region. Results: Gas chromatography/mass spectrometry (GC/MS) analysis revealed the presence of twenty-five fatty acid esters and twenty-two compounds. Column chromatography led to the isolation of nine compounds. Treatment with the seeds extract revealed improvement of the measured parameters with variable degrees. Conclusion: Chia seeds extract succeeded to attenuate the neurodegeneration in diabetic rats. Thereafter, it had a therapeutic effect and could be potentially used as a new dietary supplement against diabetic encephalopathy. |
| فهرسة مساهمة: | Keywords: Salvia hispanica L.; diabetic encephalopathy; fatty acids; neurotransmitters; oxidative stress; triterpenes |
| المشرفين على المادة: | 0 (Neurotransmitter Agents) 0 (Plant Extracts) 5W494URQ81 (Streptozocin) 9007-49-2 (DNA) EC 3.1.1.7 (Acetylcholinesterase) |
| تواريخ الأحداث: | Date Created: 20220307 Date Completed: 20220719 Latest Revision: 20220720 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/1354750X.2022.2051072 |
| PMID: | 35253573 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1366-5804 |
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| DOI: | 10.1080/1354750X.2022.2051072 |