Transcutaneous electrical nerve stimulation effects on pain-intensity and endogenous opioids levels among chronic low-back pain patients: A randomised controlled trial.

التفاصيل البيبلوغرافية
العنوان:	Transcutaneous electrical nerve stimulation effects on pain-intensity and endogenous opioids levels among chronic low-back pain patients: A randomised controlled trial.
المؤلفون:	Ezema CI; Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Nsukka, Enugu, Nigeria., Onyeso OK; Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Nsukka, Enugu, Nigeria.; Faculty of Health Sciences, University of Lethbridge, Lethbridge, Alberta, Canada.; Emerging Researchers and Professionals in Ageing-African Network, Nigeria., Nna EO; Safety Molecular Pathology Laboratory, Ranger's Avenue, Enugu, Nigeria., Awosoga OA; Faculty of Health Sciences, University of Lethbridge, Lethbridge, Alberta, Canada., Odole AC; Department of Physiotherapy, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Kalu ME; Emerging Researchers and Professionals in Ageing-African Network, Nigeria.; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., Okoye GC; Department of Medical Rehabilitation, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Nsukka, Enugu, Nigeria.
المصدر:	Journal of back and musculoskeletal rehabilitation [J Back Musculoskelet Rehabil] 2022; Vol. 35 (5), pp. 1053-1064.
نوع المنشور:	Journal Article; Randomized Controlled Trial
اللغة:	English
بيانات الدورية:	Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9201340 Publication Model: Print Cited Medium: Internet ISSN: 1878-6324 (Electronic) Linking ISSN: 10538127 NLM ISO Abbreviation: J Back Musculoskelet Rehabil Subsets: MEDLINE
أسماء مطبوعة:	Publication: 1999- : Amsterdam : Ios Press Original Publication: Reading, MA : Andover, c1991-
مواضيع طبية MeSH:	Low Back Pain/therapy , Transcutaneous Electric Nerve Stimulation, Double-Blind Method ; Humans ; Pain Management ; Pain Measurement
مستخلص:	Background: Transcutaneous electrical nerve stimulation (TENS) is a promising non-pharmacological modality for the management of chronic low back pain (CLBP), but its efficacy and mode of action have not been clearly established. Objective: To evaluate the responses of plasma beta-endorphin (βE), met-enkephalin (ME), and pain intensity (PI) among patients with CLBP exposed to TENS or sham-TENS. Methods: This double-blind trial involved 62 participants (aged 53.29 ± 5.07 years) randomised into TENS group (frequency 100 Hz, burst-rate 2 Hz, burst-width 150 μs, intensity 40 mA, duration 30 min), and sham-TENS group. The PI and plasma concentrations of βE and ME were measured at baseline, immediately (0 hr), 1 hr, 24 hrs, and 48 hrs post-intervention. Data were analysed using general linear model repeated measures, ordinal regression, one-way analysis of variance, Kruskal-Wallis test, independent and paired samples t-tests, Mann-Whitney U test, Wilcoxon signed-rank test, and Kendall's tau coefficient. Results: There was a significant temporal difference in PI between groups, F (1, 58) = 18.83, p< 0.001; the TENS group had better pain relief. The relative analgesic effect of TENS started immediately after the intervention (median difference [M⁢D] =-3, p< 0.001), peaked at 1 hr (M⁢D=-4, p< 0.001), and worn out by 24 hrs (M⁢D=-1, p= 0.029). However, there was no significant difference in βE and ME between the groups from 0 hr to 24 hrs post interventions, and no significant correlation between the PI, and βE, or ME. Conclusion: TENS significantly reduced PI up to 24 hrs after treatment.
فهرسة مساهمة:	Keywords: Beta-endorphin; TENS analgesic; met-enkephalin; physiotherapy; spondylosis
تواريخ الأحداث:	Date Created: 20220307 Date Completed: 20220913 Latest Revision: 20220913
رمز التحديث:	20221213
DOI:	10.3233/BMR-210146
PMID:	35253730
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1878-6324
DOI:	10.3233/BMR-210146