دورية أكاديمية
Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia.
| العنوان: | Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia. |
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| المؤلفون: | Waldrop G; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Safavynia SA; New York Presbyterian Hospital, New York, NY, USA.; Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA., Barra ME; Department of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.; Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, USA., Agarwal S; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Berlin DA; New York Presbyterian Hospital, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Boehme AK; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Brodie D; New York Presbyterian Hospital, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Choi JM; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA., Doyle K; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Fins JJ; New York Presbyterian Hospital, New York, NY, USA.; Division of Medical Ethics, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Ganglberger W; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hoffman K; Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA., Mittel AM; New York Presbyterian Hospital, New York, NY, USA.; Department of Anesthesia, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Roh D; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Mukerji SS; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Der Nigoghossian C; New York Presbyterian Hospital, New York, NY, USA.; Department of Pharmacy, New York Presbyterian Hospital, New York, NY, USA., Park S; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Schenck EJ; New York Presbyterian Hospital, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Salazar-Schicchi J; New York Presbyterian Hospital, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, Columbia University, New York, NY, USA., Shen Q; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Sholle E; Information Technologies & Services Department, Weill Cornell Medicine, New York, NY, USA., Velazquez AG; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA., Walline MC; New York Presbyterian Hospital, New York, NY, USA.; Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA., Westover MB; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Brown EN; Department of Brain and Cognitive Science, Institute of Medical Engineering and Sciences, the Picower Institute for Learning and Memory, and the Institute for Data Systems and Society, Massachusetts Institute of Technology, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Victor J; New York Presbyterian Hospital, New York, NY, USA.; Department of Neurology, Weill Cornell Medical College, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medical Center, New York, NY, USA., Edlow BL; Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schiff ND; New York Presbyterian Hospital, New York, NY, USA.; Department of Neurology, Weill Cornell Medical College, New York, NY, USA.; Feil Family Brain and Mind Research Institute, Weill Cornell Medical Center, New York, NY, USA., Claassen J; Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.; New York Presbyterian Hospital, New York, NY, USA. |
| المصدر: | Annals of neurology [Ann Neurol] 2022 Jun; Vol. 91 (6), pp. 740-755. Date of Electronic Publication: 2022 Apr 21. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: Boston, Little, Brown. |
| مواضيع طبية MeSH: | Brain Injuries*/complications , COVID-19*/complications, Cohort Studies ; Humans ; Hypoxia ; Retrospective Studies ; Unconsciousness/complications |
| مستخلص: | Objective: The purpose of this study was to estimate the time to recovery of command-following and associations between hypoxemia with time to recovery of command-following. Methods: In this multicenter, retrospective, cohort study during the initial surge of the United States' pandemic (March-July 2020) we estimate the time from intubation to recovery of command-following, using Kaplan Meier cumulative-incidence curves and Cox proportional hazard models. Patients were included if they were admitted to 1 of 3 hospitals because of severe coronavirus disease 2019 (COVID-19), required endotracheal intubation for at least 7 days, and experienced impairment of consciousness (Glasgow Coma Scale motor score <6). Results: Five hundred seventy-one patients of the 795 patients recovered command-following. The median time to recovery of command-following was 30 days (95% confidence interval [CI] = 27-32 days). Median time to recovery of command-following increased by 16 days for patients with at least one episode of an arterial partial pressure of oxygen (PaO Interpretation: Survivors of severe COVID-19 commonly recover consciousness weeks after cessation of mechanical ventilation. Long recovery periods are associated with more severe hypoxemia. This relationship is not explained by sedation or brain injury identified on clinical imaging and should inform decisions about life-sustaining therapies. ANN NEUROL 2022;91:740-755. (© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.) |
| التعليقات: | Comment in: Ann Neurol. 2022 Nov;92(5):906. doi: 10.1002/ana.26476. (PMID: 35960230) |
| References: | N Engl J Med. 2000 May 4;342(18):1301-8. (PMID: 10793162) Brain. 2020 Oct 1;143(10):3104-3120. (PMID: 32637987) Ann Neurol. 2020 Oct;88(4):851-854. (PMID: 32613682) Brain Pathol. 2004 Jan;14(1):21-33. (PMID: 14997934) N Engl J Med. 2020 Dec 17;383(25):2451-2460. (PMID: 32412710) Intensive Care Med. 2021 Jan;47(1):116-118. (PMID: 33034688) J Clin Ethics. 2020 Fall;31(3):219-227. (PMID: 32773404) Pharmacotherapy. 2005 Oct;25(10):1319-28. (PMID: 16185175) J Neurol Sci. 2021 Feb 15;421:117308. (PMID: 33497950) J Clin Med. 2018 Jan 30;7(2):. (PMID: 29385766) Anesth Analg. 2020 Jul;131(1):e40-e41. (PMID: 32392023) Lancet. 2020 May 2;395(10234):1417-1418. (PMID: 32325026) Neurology. 2021 Mar 9;96(10):e1437-e1442. (PMID: 33443134) Lancet. 2020 Jun 20;395(10241):e109. (PMID: 32505222) Nat Rev Nephrol. 2020 Dec;16(12):747-764. (PMID: 33060844) Radiology. 2020 Oct;297(1):E232-E235. (PMID: 32384020) Lancet. 1974 Jul 13;2(7872):81-4. (PMID: 4136544) Science. 2020 May 1;368(6490):473-474. (PMID: 32303591) Brain Sci. 2020 Nov 12;10(11):. (PMID: 33198199) NeuroRx. 2004 Jan;1(1):26-35. (PMID: 15717005) Ann Neurol. 2020 Apr;87(4):618-632. (PMID: 31994749) JAMA. 2009 Feb 4;301(5):489-99. (PMID: 19188334) Neurocrit Care. 2020 Dec;33(3):627-629. (PMID: 33174149) JAMA. 2012 Jun 20;307(23):2526-33. (PMID: 22797452) Ann Pharmacother. 2007 Feb;41(2):255-66. (PMID: 17299011) Neurology. 2022 Jan 18;98(3):e315-e325. (PMID: 34862317) N Engl J Med. 2021 Feb 4;384(5):481-483. (PMID: 33378608) N Engl J Med. 2020 Sep 3;383(10):989-992. (PMID: 32530583) Ann Neurol. 2020 Oct;88(4):653-655. (PMID: 32583426) JAMA Neurol. 2020 Jun 1;77(6):683-690. (PMID: 32275288) JAMA Neurol. 2020 Jul 02;:. (PMID: 32614385) |
| معلومات مُعتمدة: | K23 HL151876 United States HL NHLBI NIH HHS; DP2 HD101400 United States HD NICHD NIH HHS; R03NS112760 United States NS NINDS NIH HHS; R21 NS109627 United States NS NINDS NIH HHS; R01NS106014 United States NS NINDS NIH HHS |
| تواريخ الأحداث: | Date Created: 20220307 Date Completed: 20220517 Latest Revision: 20240923 |
| رمز التحديث: | 20240923 |
| مُعرف محوري في PubMed: | PMC9082460 |
| DOI: | 10.1002/ana.26342 |
| PMID: | 35254675 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-8249 |
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| DOI: | 10.1002/ana.26342 |