دورية أكاديمية
Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation.
| العنوان: | Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation. |
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| المؤلفون: | Vicentini FA; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Inflammation Research Network, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Szamosi JC; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada., Rossi L; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada., Griffin L; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Nieves K; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Inflammation Research Network, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Bihan D; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Lewis IA; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Pittman QJ; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Swain MG; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Division of Gastroenterology and Hepatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Surette MG; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada., Hirota SA; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Inflammation Research Network, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Sharkey KA; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address: ksharkey@ucalgary.ca. |
| المصدر: | Brain, behavior, and immunity [Brain Behav Immun] 2022 May; Vol. 102, pp. 266-278. Date of Electronic Publication: 2022 Mar 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : Amsterdam : Elsevier Original Publication: San Diego : Academic Press, [c1987- |
| مواضيع طبية MeSH: | Colitis*/chemically induced , Inflammatory Bowel Diseases* , Microbiota*, Animals ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Inflammation ; Male ; Mice ; Mice, Inbred C57BL |
| مستخلص: | Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. IBD are associated with a high prevalence of cognitive, behavioural and emotional comorbidities, including anxiety and depression. The link between IBD and the development of behavioural comorbidities is poorly understood. As the intestinal microbiota profoundly influences host behaviour, we sought to determine whether the altered gut microbiota associated with intestinal inflammation contributes to the development of behavioural abnormalities. Using the dextran sulphate sodium (DSS) model of colitis, we characterized intestinal inflammation, behaviour (elevated plus maze and tail suspension test) and the composition of the microbiota in male mice. Cecal contents from colitic mice were transferred into germ-free (GF) or antibiotic (Abx)-treated mice, and behaviour was characterized in recipient mice. Gene expression was measured using qPCR. DSS colitis was characterized by a significant reduction in body weight and an increase in colonic inflammatory markers. These changes were accompanied by increased anxiety-like behaviour, an altered gut microbiota composition, and increased central Tnf expression. Transfer of the cecal matter from colitic mice induced similar behavioural changes in both GF and Abx-treated recipient mice, with no signs of colonic or neuroinflammation. Upon characterization of the microbiota in donor and recipient mice, specific taxa were found to be associated with behavioural changes, notably members of the Lachnospiraceae family. Behavioural abnormalities associated with intestinal inflammation are transmissible via transfer of cecal matter, suggesting that alterations in the composition of the gut microbiota play a key role in driving behavioural changes in colitis. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anxiety; Colitis; Depression; Fecal microbiota transplant; Gut-brain axis; Inflammatory bowel disease; Neuroinflammation |
| المشرفين على المادة: | 9042-14-2 (Dextran Sulfate) |
| تواريخ الأحداث: | Date Created: 20220308 Date Completed: 20220412 Latest Revision: 20220601 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bbi.2022.03.001 |
| PMID: | 35259427 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1090-2139 |
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| DOI: | 10.1016/j.bbi.2022.03.001 |