Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation.
| العنوان: | Gut microbiome dysbiosis during COVID-19 is associated with increased risk for bacteremia and microbial translocation. |
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| المؤلفون: | Venzon M; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA., Bernard-Raichon L; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA., Klein J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Axelrad JE; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Zhang C; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Hussey GA; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Sullivan AP; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA., Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Noval MG; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Valero-Jimenez AM; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Gago J; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA., Putzel G; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Pironti A; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Wilder E; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA., Thorpe LE; Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Littman DR; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD., Dittmann M; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Stapleford KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA., Shopsin B; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD., Cadwell K; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University Grossman School of Medicine, New York, NY, USA.; Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA., Schluter J; Institute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.; Department of Microbiology, New York University Grossman School of Medicine, New York, NY, USA.; Antimicrobial-Resistant Pathogens Program, New York University School of Medicine, New York, NY, USA. |
| مؤلفون مشاركون: | Yale IMPACT Research Team |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2022 Mar 02. Date of Electronic Publication: 2022 Mar 02. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | The microbial populations in the gut microbiome have recently been associated with COVID-19 disease severity. However, a causal impact of the gut microbiome on COVID-19 patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. Antibiotics and other treatments during COVID-19 can potentially confound microbiome associations. We therefore first demonstrate in a mouse model that SARS-CoV-2 infection can induce gut microbiome dysbiosis, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Comparison with stool samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, paralleling our observations in the animal model. Specifically, we observed blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species in hospitalized COVID-19 patients. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data obtained from these patients indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19. |
| التعليقات: | Update in: Nat Commun. 2022 Nov 1;13(1):5926. (PMID: 36319618) |
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| معلومات مُعتمدة: | P30 CA016087 United States CA NCI NIH HHS; R01 DK093668 United States DK NIDDK NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS; R21 AI139374 United States AI NIAID NIH HHS; OT2 HL161847 United States HL NHLBI NIH HHS; R01 AI140754 United States AI NIAID NIH HHS; R01 AI130945 United States AI NIAID NIH HHS; S10 OD021747 United States OD NIH HHS; R01 AI121244 United States AI NIAID NIH HHS; T32 AI100853 United States AI NIAID NIH HHS; R01 AI143639 United States AI NIAID NIH HHS; R01 HL123340 United States HL NHLBI NIH HHS; DP2 AI164318 United States AI NIAID NIH HHS; R01 DK124336 United States DK NIDDK NIH HHS |
| تواريخ الأحداث: | Date Created: 20220309 Latest Revision: 20230509 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8902880 |
| DOI: | 10.1101/2021.07.15.452246 |
| PMID: | 35262080 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2021.07.15.452246 |
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