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Lung function impairment in relation to cognition and vascular brain lesions: the Rotterdam Study.

التفاصيل البيبلوغرافية
العنوان: Lung function impairment in relation to cognition and vascular brain lesions: the Rotterdam Study.
المؤلفون: Xiao T; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Wijnant SRA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., van der Velpen I; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Terzikhan N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Lahousse L; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Ikram MK; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Vernooij MW; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Brusselle GG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. guy.brusselle@UGent.be.; Department of Respiratory Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. guy.brusselle@UGent.be.; Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. guy.brusselle@UGent.be., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. m.a.ikram@erasmusmc.nl.
المصدر: Journal of neurology [J Neurol] 2022 Aug; Vol. 269 (8), pp. 4141-4153. Date of Electronic Publication: 2022 Mar 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York, Springer-Verlag
مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/complications , Pulmonary Disease, Chronic Obstructive*/diagnostic imaging , Pulmonary Disease, Chronic Obstructive*/epidemiology , Stroke, Lacunar*, Brain/diagnostic imaging ; Cognition ; Cross-Sectional Studies ; Humans ; Lung/diagnostic imaging ; Risk Factors
مستخلص: Objective: To investigate the association of chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) with cognitive performance and presence of vascular brain lesions (VBL).
Methods: We determined both cross-sectional and longitudinal association of lung function impairment with cognition, as well as cross-sectional association of lung function impairment with VBL, in the general population. Between 2009 and 2014 we included 3,941 participants from the Rotterdam Study with spirometry tests, brain MRI scans and cognition tests, of whom 1815 had follow-up data on cognition.
Results: Our finding indicated that cross-sectionally, participants with PRISm or COPD GOLD2-4 had a worse global cognitive performance. We did not find differences in cognition over time between those with normal spirometry versus those with lung function impairment. In addition, PRISm and COPD GOLD2-4 were associated with a higher prevalence of lacunar infarcts compared to normal spirometry.
Conclusions: This study suggests that persons with COPD GOLD2-4 or restrictive lung function, defined as PRISm, are characterized by poorer global cognitive function and a higher prevalence of lacunar infarcts.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
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معلومات مُعتمدة: 3G037618 Nederlandse Organisatie voor Wetenschappelijk Onderzoek
فهرسة مساهمة: Keywords: COPD; Cognition; Lung function; PRISm; Vascular brain lesions
تواريخ الأحداث: Date Created: 20220310 Date Completed: 20220720 Latest Revision: 20220720
رمز التحديث: 20231215
DOI: 10.1007/s00415-022-11027-9
PMID: 35267082
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1459
DOI:10.1007/s00415-022-11027-9