دورية أكاديمية
أعرض في EDS

Variants in the VDR Gene May Influence 25(OH)D Levels in Type 1 Diabetes Mellitus in a Brazilian Population.

التفاصيل البيبلوغرافية
العنوان: Variants in the VDR Gene May Influence 25(OH)D Levels in Type 1 Diabetes Mellitus in a Brazilian Population.
المؤلفون: Ferraz RS; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil., Silva CS; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil., Cavalcante GC; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil., de Queiroz NNM; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil., Felício KM; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil., Felício JS; Endocrinology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66075-110, PA, Brazil., Ribeiro-Dos-Santos Â; Laboratory of Human and Medical Genetics, Federal University of Para, Belem 66075-110, PA, Brazil.; Oncology Research Center, Joao de Barros Barreto University Hospital, Federal University of Para, Belem 66073-000, PA, Brazil.
المصدر: Nutrients [Nutrients] 2022 Feb 27; Vol. 14 (5). Date of Electronic Publication: 2022 Feb 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Diabetes Mellitus, Type 1*/genetics, Brazil ; Genetic Predisposition to Disease ; Humans ; Receptors, Calcitriol/genetics ; Vitamin D/analogs & derivatives
مستخلص: Vitamin D has been considered a strong contributing factor to type 1 diabetes mellitus (T1DM). Many studies have investigated polymorphisms in the VDR gene in association with T1DM in different populations, but there are still conflicting findings. This study aimed to evaluate the association of four variants in the VDR gene (rs7975232, rs1544410, rs731236, and rs2228570) with T1DM risk and vitamin D levels within a population from North Region, Brazil, as well as the influence of genomic ancestry on T1DM. A total of 65 T1DM patients and 83 non-T1DM patients were enrolled in this study. VDR gene polymorphisms were assessed using Sanger sequencing analysis. Genomic ancestry was analyzed using a set of 61 ancestry-informative markers. T1DM patients showed higher European genomic contribution and lower Native American genomic contribution when compared to non-T1DM patients. T1DM patients with AA genotype in rs1544410 or CC genotype in rs731236 had significantly lower 25(OH)D levels compared to the other two genotypes ( p = 0.013 and p = 0.02, respectively), while T1DM with TT genotype in rs2228570 had higher 25(OH)D levels compared to CC + TC in the same polymorphism ( p = 0.011). Our findings suggest that the association between 25(OH)D and T1DM may be modified by VDR variants, possibly influencing the development of this autoimmune disease.
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معلومات مُعتمدة: 3381/2013 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: 25(OH)D; Type 1 diabetes; genetic polymorphism; genomic ancestry; vitamin D receptor
المشرفين على المادة: 0 (Receptors, Calcitriol)
0 (VDR protein, human)
1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
تواريخ الأحداث: Date Created: 20220310 Date Completed: 20220314 Latest Revision: 20220531
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8912721
DOI: 10.3390/nu14051010
PMID: 35267984
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14051010