دورية أكاديمية

Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study.

التفاصيل البيبلوغرافية
العنوان: Vitamin D Concentrations at Birth and the Risk of Rheumatoid Arthritis in Early Adulthood: A Danish Population-Based Case-Cohort Study.
المؤلفون: Cardoso I; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark., Specht IO; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark., Thorsteinsdottir F; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark., Thorbek MJ; Center for Neonatal Screening, Department of Congenital Disorders-Clinical Mass Spectrometry, Statens Serum Institute, 2300 Copenhagen, Denmark., Keller A; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark.; Section of Epidemiology, Department of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark., Stougaard M; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark.; Center for Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, 1353 Copenhagen, Denmark., Cohen AS; Clinical Mass Spectrometry, Staten Serum Institute, 2300 Copenhagen, Denmark., Händel MN; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark., Kristensen LE; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark., Heitmann BL; The Parker Institute, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark.; Center for Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, 1353 Copenhagen, Denmark.; The Boden Group, Faculty of Medicine and Health, Sydney University, Sydney, NSW 2006, Australia.; Section for Clinical Practice, Department of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.
المصدر: Nutrients [Nutrients] 2022 Jan 20; Vol. 14 (3). Date of Electronic Publication: 2022 Jan 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Arthritis, Rheumatoid*/epidemiology , Arthritis, Rheumatoid*/etiology , Vitamin D*, Adolescent ; Adult ; Child ; Cohort Studies ; Denmark/epidemiology ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Vitamins
مستخلص: Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981−1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.
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معلومات مُعتمدة: Gigtforeningen; Dagmar Marshalls Fond; Kong Christian den Tiendes Fond; 0603-00453B the Programme Commission on Health, Food and Welfare under the Danish Council for Strategic research
فهرسة مساهمة: Keywords: Denmark; cohort; dried blood spots; early adulthood; rheumatoid arthritis; vitamin D
المشرفين على المادة: 0 (Vitamins)
1406-16-2 (Vitamin D)
تواريخ الأحداث: Date Created: 20220312 Date Completed: 20220315 Latest Revision: 20230308
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8839203
DOI: 10.3390/nu14030447
PMID: 35276806
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14030447