دورية أكاديمية
أعرض في EDS

Hydrolyzed Proteins and Vegetable Peptides: Anti-Inflammatory Mechanisms in Obesity and Potential Therapeutic Targets.

التفاصيل البيبلوغرافية
العنوان: Hydrolyzed Proteins and Vegetable Peptides: Anti-Inflammatory Mechanisms in Obesity and Potential Therapeutic Targets.
المؤلفون: de Medeiros AF; Postgraduate Biochemistry and Biology Molecular Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., de Queiroz JLC; Postgraduate Biochemistry and Biology Molecular Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., Maciel BLL; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil., de Araújo Morais AH; Postgraduate Biochemistry and Biology Molecular Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.; Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal 59078-970, RN, Brazil.
المصدر: Nutrients [Nutrients] 2022 Feb 06; Vol. 14 (3). Date of Electronic Publication: 2022 Feb 06.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Obesity*/etiology , Vegetables*/metabolism, Adipokines/metabolism ; Adipose Tissue/metabolism ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
مستخلص: Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumulation of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is challenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies.
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معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 426116/2018-6 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: amino acids; anti-inflammatory agents; anti-obesity agents; inflammation mediators; peptides and proteins
المشرفين على المادة: 0 (Adipokines)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20220312 Date Completed: 20220315 Latest Revision: 20220315
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8838308
DOI: 10.3390/nu14030690
PMID: 35277049
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu14030690