دورية أكاديمية
أعرض في EDS

Feasibility of a prototype carbon nanotube enabled stationary digital chest tomosynthesis system for identification of pulmonary nodules by pulmonologists.

التفاصيل البيبلوغرافية
العنوان: Feasibility of a prototype carbon nanotube enabled stationary digital chest tomosynthesis system for identification of pulmonary nodules by pulmonologists.
المؤلفون: Burks AC; Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, NC, USA., Akulian J; Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, NC, USA., MacRosty CR; Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, NC, USA., Ghosh S; Division of Pulmonary and Critical Care, Allegheny Health Network, Pittsburgh, PA, USA., Belanger A; FirstHealth, Pinehurst Medical Clinic, Pinehurst, NC, USA., Sakthivel M; Department of Radiology, University of North Carolina at Chapel Hill, NC, USA., Benefield TS; Department of Radiology, University of North Carolina at Chapel Hill, NC, USA., Inscoe CR; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, NC, USA., Zhou O; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, NC, USA., Lu J; Department of Physics and Astronomy, University of North Carolina at Chapel Hill, NC, USA., Lee YZ; Department of Radiology, University of North Carolina at Chapel Hill, NC, USA.
المصدر: Journal of thoracic disease [J Thorac Dis] 2022 Feb; Vol. 14 (2), pp. 257-268.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: AME Publishing Company Country of Publication: China NLM ID: 101533916 Publication Model: Print Cited Medium: Print ISSN: 2072-1439 (Print) Linking ISSN: 20721439 NLM ISO Abbreviation: J Thorac Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Hong Kong : AME Publishing Company
Original Publication: Hong Kong : Pioneer Bioscience Pub. Co.
مستخلص: Background: Screen detected and incidental pulmonary nodules are increasingly common. Current guidelines recommend tissue sampling of solid nodules >8 mm. Bronchoscopic biopsy poses the lowest risk but is paired with the lowest diagnostic yield when compared to CT-guided biopsy or surgery. A need exists for a safe, mobile, low radiation dose, intra-procedural method to localize biopsy instruments within target nodules. This retrospective cross sectional reader feasibility study evaluates the ability of clinicians to identify pulmonary nodules using a prototype carbon nanotube radiation enabled stationary digital chest tomosynthesis system.
Methods: Patients with pulmonary nodules on prior CT imaging were recruited and consented for imaging with stationary digital chest tomosynthesis. Five pulmonologists of varying training levels participated as readers. Following review of patient CT and a thoracic radiologist's interpretation of nodule size and location the readers were tasked with interpreting the corresponding tomosynthesis scan to identify the same nodule found on CT.
Results: Fifty-five patients were scanned with stationary digital chest tomosynthesis. The median nodule size was 6 mm (IQR =4-13 mm). Twenty nodules (37%) were greater than 8 mm. The radiation entrance dose for s-DCT was 0.6 mGy. A significant difference in identification of nodules using s-DCT was seen for nodules <8 vs. ≥8 mm in size (57.7% vs. 90.9%, CI: -0.375, -0.024; P<0.001). Inter-reader agreement was fair, and better for nodules ≥8 mm [0.278 (SE =0.043)].
Conclusions: With system and carbon nanotube array optimization, we hypothesize the detection rate for nodules will improve. Additional study is needed to evaluate its use in target and tool co-localization and target biopsy.
Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-21-1381/coif) and report that the current study was partially funded by the institutional University Cancer Research Fund via a Lineberger Comprehensive Clinical Cancer Center award. CI reports that she is co-inventor of the tomosynthesis system and received royalties from UNC for the intellectual property (IP). OZ, JL, CI and YL are co-inventors of the stationary chest tomosynthesis imaging system evaluated in this study. OZ and JL are co-owners of Xintek, Inc., the company to which the technology has been licensed. OZ and JL report that they are shareholders and consultants for the company that the IP is licensed to. YL reports that he is co-inventor of the system, but does not receive financial or other interests from the IP. The authors have no other conflicts of interest to declare.
(2022 Journal of Thoracic Disease. All rights reserved.)
References: N Engl J Med. 2011 Aug 4;365(5):395-409. (PMID: 21714641)
Med Phys. 2011 Aug;38(8):4563-74. (PMID: 21928628)
Acad Radiol. 2014 Nov;21(11):1427-33. (PMID: 25097012)
Semin Ultrasound CT MR. 2002 Oct;23(5):402-10. (PMID: 12509110)
Radiat Prot Dosimetry. 2010 Apr-May;139(1-3):153-8. (PMID: 20233755)
Chest. 1993 Oct;104(4):1021-4. (PMID: 8404158)
Am J Respir Crit Care Med. 2016 Jan 1;193(1):68-77. (PMID: 26367186)
Chest. 2015 May;147(5):1275-1281. (PMID: 25357229)
J Thorac Dis. 2015 May;7(5):799-809. (PMID: 26101635)
J Bronchology Interv Pulmonol. 2018 Oct;25(4):274-282. (PMID: 30179922)
Med Phys. 2021 Mar;48(3):1089-1099. (PMID: 33382470)
Korean J Radiol. 2013 May-Jun;14(3):525-31. (PMID: 23690724)
Phys Med Biol. 2003 Oct 7;48(19):R65-106. (PMID: 14579853)
Chest. 2013 May;143(5 Suppl):e93S-e120S. (PMID: 23649456)
Semin Respir Crit Care Med. 2014 Feb;35(1):17-26. (PMID: 24481756)
J Thorac Dis. 2020 Apr;12(4):1595-1611. (PMID: 32395297)
Laryngoscope. 2009 Mar;119(3):434-41. (PMID: 19235745)
Eur Radiol. 2020 Oct;30(10):5437-5445. (PMID: 32382844)
Eur Respir J. 2011 Apr;37(4):902-10. (PMID: 20693253)
N Engl J Med. 2013 Sep 5;369(10):910-9. (PMID: 24004118)
Proc SPIE Int Soc Opt Eng. 2010;7622:76220H. (PMID: 27053823)
Surg Endosc. 2020 Jan;34(1):477-484. (PMID: 31309308)
Med Phys. 2016 Dec;43(12):6282. (PMID: 27908166)
Radiographics. 2012 Sep-Oct;32(5):E201-32. (PMID: 22977038)
Chest. 2012 Aug;142(2):385-393. (PMID: 21980059)
Head Neck. 2010 Apr;32(4):504-12. (PMID: 19693942)
AJR Am J Roentgenol. 2007 Feb;188(2):433-40. (PMID: 17242253)
Int J Cardiovasc Imaging. 2011 Dec;27(8):1205-22. (PMID: 21394614)
N Engl J Med. 2011 Nov 24;365(21):2036; author reply 2037-8. (PMID: 22111730)
Eur J Radiol. 2009 Nov;72(2):244-51. (PMID: 19616909)
Clin Radiol. 2008 Mar;63(3):272-7. (PMID: 18275867)
Radiology. 2017 Jul;284(1):228-243. (PMID: 28240562)
Glob J Health Sci. 2015 Feb 24;7(5):202-7. (PMID: 26156930)
Med Phys. 2003 Dec;30(12):3135-42. (PMID: 14713080)
Ann Surg. 2011 Aug;254(2):368-74. (PMID: 21617585)
Med Phys. 2009 Dec;36(12):5480-7. (PMID: 20095260)
J Natl Cancer Inst. 2020 Jun 1;112(6):582-589. (PMID: 31503283)
Ann Am Thorac Soc. 2014 May;11(4):578-82. (PMID: 24635641)
Eur Radiol. 2019 Apr;29(4):1665-1673. (PMID: 30255248)
Med Phys. 2000 Aug;27(8):1903-14. (PMID: 10984236)
Med Phys. 2009 Oct;36(10):4389-99. (PMID: 19928069)
Am J Respir Crit Care Med. 2015 Nov 15;192(10):1208-14. (PMID: 26214244)
Cureus. 2016 Sep 12;8(9):e778. (PMID: 27752404)
Med Phys. 2018 Nov;45(11):5172-5185. (PMID: 30259988)
Chest. 2007 Jun;131(6):1800-5. (PMID: 17400670)
Radiology. 2008 Dec;249(3):1034-41. (PMID: 18849504)
Gen Thorac Cardiovasc Surg. 2018 Nov;66(11):626-631. (PMID: 30062622)
J Med Assoc Thai. 2007 Nov;90 Suppl 2:68-73. (PMID: 19230427)
Med Phys. 2008 Jun;35(6):2554-7. (PMID: 18649488)
فهرسة مساهمة: Keywords: Tomosynthesis; bronchoscopy; chest imaging; lung cancer; pulmonary nodules
تواريخ الأحداث: Date Created: 20220314 Latest Revision: 20220315
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8902128
DOI: 10.21037/jtd-21-1381
PMID: 35280479
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-1439
DOI:10.21037/jtd-21-1381