دورية أكاديمية
The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension.
| العنوان: | The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension. |
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| المؤلفون: | Nayler WG, Yepez CE, Poole-Wilson PA |
| المصدر: | Cardiovascular research [Cardiovasc Res] 1978 Nov; Vol. 12 (11), pp. 666-74. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Print ISSN: 0008-6363 (Print) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2008- : Oxford : Oxford Journals Original Publication: London, British Medical Assn. |
| مواضيع طبية MeSH: | Adrenergic beta-Antagonists/*pharmacology , Calcium/*pharmacology , Hypoxia/*physiopathology , Myocardial Contraction/*drug effects, Animals ; Depression, Chemical ; Guinea Pigs ; Heart Rate ; Hyperthyroidism/physiopathology ; In Vitro Techniques ; Male ; Reserpine/pharmacology ; Stimulation, Chemical ; Verapamil/pharmacology |
| مستخلص: | Using isolated, Langendorff-perfused, electrically-paced guinea-pig hearts, we have investigated the rise in resting tension that occurs when mammalian heart muscle becomes hypoxic. Substrate-depletion, tachycardia, hyperthyroidism, and inotropic interventions (ouabain, isoprenaline, and beta-receptor antagonists at concentrations which increase inotropic state) enhanced the rate of development of this increase in resting tension. 3.86 mumol.litre-1 propranolol, 0.22 to 2.20 mumol.litre-1 verapamil or removing Ca2+ from the extracellular phase at the start of the hypoxic episode prevented (or delayed) the rise in resting tension. Adding these same agents or removing Ca2+ from the extracellular phase after the hypoxia-induced rise in resting tension had started to develop failed to prevent its progression. These results provide some support for an hypothesis that the hypoxia-induced increase in resting tension is independent of an enhanced Ca2+ influx. |
| المشرفين على المادة: | 0 (Adrenergic beta-Antagonists) 8B1QWR724A (Reserpine) CJ0O37KU29 (Verapamil) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19781101 Date Completed: 19790725 Latest Revision: 20190509 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/cvr/12.11.666 |
| PMID: | 35282 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0008-6363 |
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| DOI: | 10.1093/cvr/12.11.666 |