دورية أكاديمية
أعرض في EDS

Infection with intestinal helminth (Hymenolepis diminuta) impacts exploratory behavior and cognitive processes in rats by changing the central level of neurotransmitters.

التفاصيل البيبلوغرافية
العنوان: Infection with intestinal helminth (Hymenolepis diminuta) impacts exploratory behavior and cognitive processes in rats by changing the central level of neurotransmitters.
المؤلفون: Blecharz-Klin K; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Świerczyńska M; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Piechal A; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Wawer A; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Joniec-Maciejak I; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Pyrzanowska J; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Wojnar E; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Zawistowska-Deniziak A; W. Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland., Sulima-Celińska A; Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland., Młocicki D; W. Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland.; Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland., Mirowska-Guzel D; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland.
المصدر: PLoS pathogens [PLoS Pathog] 2022 Mar 14; Vol. 18 (3), pp. e1010330. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Helminths* , Hymenolepiasis*/parasitology , Hymenolepis diminuta*/physiology, Animals ; Cognition ; Exploratory Behavior ; Helminthiasis ; Interleukin-6 ; Intestinal Diseases, Parasitic ; Neurotransmitter Agents ; Rats
مستخلص: Parasites may significantly affect the functioning of the host organism including immune response and gut-brain-axis ultimately leading to alteration of the host behavior. The impact of intestinal worms on the host central nervous system (CNS) remains unexplored. The aim of this study was to evaluate the effect of intestinal infection by the tapeworm Hymenolepis diminuta on behavior and functions of the CNS in rats. The 3 months old animals were infected, and the effects on anxiety, exploration, sensorimotor skills and learning processes were assessed at 18 months in Open Field (OF), Novel Object Recognition (NOR) and the Water Maze (WM) tests. After completing the behavioral studies, both infected and non-infected rats were sacrificed, and the collected tissues were subjected to biochemical analysis. The levels of neurotransmitters, their metabolites and amino acids in selected structures of the CNS were determined by HPLC. In addition, the gene expression profile of the pro- and anti-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-10) was evaluated by Real-Time PCR to determine the immune response within the CNS to the tapeworm infection. The parasites caused significant changes in exploratory behavior, most notably, a reduction of velocity and total distance moved in the OF test; the infected rats exhibited decreased frequency in the central zone, which may indicate a higher level of anxiety. Additionally, parasite infestation improved spatial memory, assessed in the WM test, and recognition of new objects. These changes are related to the identified reduction in noradrenaline level in the CNS structures and less pronounced changes in striatal serotonergic neurotransmission. H. diminuta infestation was also found to cause a significant reduction of hippocampal expression of IL-6. Our results provide new data for further research on brain function during parasitic infections especially in relation to helminths and diseases in which noradrenergic system may play an important role.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Interleukin-6)
0 (Neurotransmitter Agents)
SCR Disease Name: Intestinal helminthiasis
تواريخ الأحداث: Date Created: 20220314 Date Completed: 20220422 Latest Revision: 20220422
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8947016
DOI: 10.1371/journal.ppat.1010330
PMID: 35286352
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1010330