دورية أكاديمية
Infection with intestinal helminth (Hymenolepis diminuta) impacts exploratory behavior and cognitive processes in rats by changing the central level of neurotransmitters.
العنوان: | Infection with intestinal helminth (Hymenolepis diminuta) impacts exploratory behavior and cognitive processes in rats by changing the central level of neurotransmitters. |
---|---|
المؤلفون: | Blecharz-Klin K; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Świerczyńska M; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Piechal A; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Wawer A; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Joniec-Maciejak I; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Pyrzanowska J; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Wojnar E; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland., Zawistowska-Deniziak A; W. Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland., Sulima-Celińska A; Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland., Młocicki D; W. Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland.; Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland., Mirowska-Guzel D; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Warsaw, Poland. |
المصدر: | PLoS pathogens [PLoS Pathog] 2022 Mar 14; Vol. 18 (3), pp. e1010330. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022). |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science, c2005- |
مواضيع طبية MeSH: | Helminths* , Hymenolepiasis*/parasitology , Hymenolepis diminuta*/physiology, Animals ; Cognition ; Exploratory Behavior ; Helminthiasis ; Interleukin-6 ; Intestinal Diseases, Parasitic ; Neurotransmitter Agents ; Rats |
مستخلص: | Parasites may significantly affect the functioning of the host organism including immune response and gut-brain-axis ultimately leading to alteration of the host behavior. The impact of intestinal worms on the host central nervous system (CNS) remains unexplored. The aim of this study was to evaluate the effect of intestinal infection by the tapeworm Hymenolepis diminuta on behavior and functions of the CNS in rats. The 3 months old animals were infected, and the effects on anxiety, exploration, sensorimotor skills and learning processes were assessed at 18 months in Open Field (OF), Novel Object Recognition (NOR) and the Water Maze (WM) tests. After completing the behavioral studies, both infected and non-infected rats were sacrificed, and the collected tissues were subjected to biochemical analysis. The levels of neurotransmitters, their metabolites and amino acids in selected structures of the CNS were determined by HPLC. In addition, the gene expression profile of the pro- and anti-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-10) was evaluated by Real-Time PCR to determine the immune response within the CNS to the tapeworm infection. The parasites caused significant changes in exploratory behavior, most notably, a reduction of velocity and total distance moved in the OF test; the infected rats exhibited decreased frequency in the central zone, which may indicate a higher level of anxiety. Additionally, parasite infestation improved spatial memory, assessed in the WM test, and recognition of new objects. These changes are related to the identified reduction in noradrenaline level in the CNS structures and less pronounced changes in striatal serotonergic neurotransmission. H. diminuta infestation was also found to cause a significant reduction of hippocampal expression of IL-6. Our results provide new data for further research on brain function during parasitic infections especially in relation to helminths and diseases in which noradrenergic system may play an important role. Competing Interests: The authors have declared that no competing interests exist. |
References: | Neurobiol Learn Mem. 2018 Nov;155:21-29. (PMID: 29908286) Sci Rep. 2019 May 27;9(1):7868. (PMID: 31133690) Gastroenterology. 1991 Mar;100(3):675-82. (PMID: 1847118) Neurochem Int. 2001 Apr;38(4):303-8. (PMID: 11137624) Int J Biochem Cell Biol. 2020 Aug;125:105776. (PMID: 32479926) J Immunol. 2011 Jul 1;187(1):350-60. (PMID: 21606248) Eur Cytokine Netw. 1999 Mar;10(1):57-64. (PMID: 10210774) Behav Brain Res. 1993 Apr 30;54(2):179-85. (PMID: 8323714) Biol Open. 2020 Jul 8;9(7):. (PMID: 32439741) Nat Rev Rheumatol. 2017 Jul;13(7):399-409. (PMID: 28615731) J Anim Ecol. 2018 Mar;87(2):438-447. (PMID: 28555881) Sci Rep. 2015 Mar 11;5:9009. (PMID: 25760924) Parasit Vectors. 2017 Nov 21;10(1):577. (PMID: 29157281) Biochim Biophys Acta. 2013 Mar;1832(3):485-94. (PMID: 23253440) Nat Rev Neurosci. 2009 Mar;10(3):211-23. (PMID: 19190638) Parasitology. 2018 Sep;145(10):1324-1335. (PMID: 29909781) Can J Physiol Pharmacol. 1981 Mar;59(3):281-6. (PMID: 7225951) Pharmacol Biochem Behav. 2018 May;168:25-32. (PMID: 29545027) Microbiome. 2021 Sep 13;9(1):186. (PMID: 34517928) Can J Psychiatry. 2011 Dec;56(12):707-15. (PMID: 22152639) Metab Brain Dis. 2020 Jan;35(1):95-110. (PMID: 31352539) Brain Behav Immun. 2011 Feb;25(2):181-213. (PMID: 20970492) Nat Protoc. 2006;1(2):848-58. (PMID: 17406317) Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. (PMID: 25830558) Gut Microbes. 2015;6(3):182-93. (PMID: 25942385) FASEB J. 2004 Nov;18(14):1788-90. (PMID: 15345694) Adv Parasitol. 1999;42:223-75. (PMID: 10050274) J Neurosci Methods. 1995 Mar;57(1):93-9. (PMID: 7791370) J Neuroinflammation. 2021 Feb 16;18(1):45. (PMID: 33593388) Front Immunol. 2017 Feb 20;8:148. (PMID: 28265273) J Biomed Biotechnol. 2010;2010:384523. (PMID: 20011066) Biomed Res. 2020;41(5):199-216. (PMID: 33071256) Neurochem Res. 1999 Sep;24(9):1169-80. (PMID: 10485589) Gastroenterology. 2019 Aug;157(2):507-521.e4. (PMID: 31071306) Nat Rev Microbiol. 2021 Apr;19(4):241-255. (PMID: 33093662) Brain Behav Immun. 2016 Jan;51:14-28. (PMID: 26162711) Nutrients. 2021 Jan 27;13(2):. (PMID: 33513791) PLoS One. 2019 Dec 4;14(12):e0226044. (PMID: 31800640) Front Immunol. 2018 Nov 12;9:2487. (PMID: 30483248) Acta Parasitol. 2016 Mar;61(2):429-42. (PMID: 27078671) J Egypt Soc Parasitol. 1996 Aug;26(2):497-508. (PMID: 8754657) Eur Cytokine Netw. 2012 Jul-Sep;23(3):112-9. (PMID: 23009764) Nucleic Acids Res. 2001 May 1;29(9):e45. (PMID: 11328886) Immunol Rev. 2014 Jul;260(1):183-205. (PMID: 24942690) Transl Psychiatry. 2020 Jul 3;10(1):213. (PMID: 32620743) PLoS One. 2013 Nov 01;8(11):e77779. (PMID: 24223727) Science. 2003 Dec 5;302(5651):1760-5. (PMID: 14615545) Handb Exp Pharmacol. 2018;248:397-431. (PMID: 29236160) Endocrinology. 2017 May 1;158(5):1049-1063. (PMID: 28323941) Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:136-151. (PMID: 28803923) Neuropharmacology. 2015 Sep;96(Pt A):42-54. (PMID: 25445486) Nat Rev Gastroenterol Hepatol. 2009 May;6(5):306-14. (PMID: 19404271) J Neural Transm (Vienna). 2018 Jan;125(1):53-66. (PMID: 28293733) Behav Brain Res. 1988 Nov 1;31(1):47-59. (PMID: 3228475) Front Microbiol. 2018 Jan 15;8:2672. (PMID: 29379475) PLoS One. 2017 Aug 3;12(8):e0182205. (PMID: 28771620) Parasitology. 2010 Mar;137(3):385-94. (PMID: 19691904) |
المشرفين على المادة: | 0 (Interleukin-6) 0 (Neurotransmitter Agents) |
SCR Disease Name: | Intestinal helminthiasis |
تواريخ الأحداث: | Date Created: 20220314 Date Completed: 20220422 Latest Revision: 20220422 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8947016 |
DOI: | 10.1371/journal.ppat.1010330 |
PMID: | 35286352 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1553-7374 |
---|---|
DOI: | 10.1371/journal.ppat.1010330 |