دورية أكاديمية
Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making.
| العنوان: | Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making. |
|---|---|
| المؤلفون: | Naiche LA; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA., Villa SR; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA.; University of Illinois Cancer Center, Chicago, Illinois 60612, USA. |
| المصدر: | Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2022 Nov 01; Vol. 12 (11). Date of Electronic Publication: 2022 Nov 01. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Woodbury, NY : Cold Spring Harbor Laboratory Press, c2011- |
| مواضيع طبية MeSH: | Receptors, Notch* , Endothelial Cells*, Humans ; Signal Transduction ; Cell Differentiation ; Morphogenesis ; Neovascularization, Physiologic |
| مستخلص: | As vascular networks form, endothelial cells (ECs) undergo cell fate decisions that determine whether they become tip or stalk cells of the developing vascular plexus or mature into arterial, venous, or lymphatic endothelium. EC fate decisions are coordinated with neighboring cells to initiate sprouting, maintain endothelial barrier, or ensure appropriate specialization of vessels. We describe mechanisms that control EC fate at specific steps in these processes, with an emphasis on the role of the Notch signaling pathway. Specific EC fate determination steps that are highlighted are tip/stalk selection during sprouting angiogenesis, venous-arterial specification, arteriogenesis, lymphatic vessel specification, and lymphatic valve formation. (Copyright © 2022 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| معلومات مُعتمدة: | K99 NS126732 United States NS NINDS NIH HHS; R01 HL112626 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Receptors, Notch) |
| تواريخ الأحداث: | Date Created: 20220315 Date Completed: 20221103 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC9619357 |
| DOI: | 10.1101/cshperspect.a041183 |
| PMID: | 35288401 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2157-1422 |
|---|---|
| DOI: | 10.1101/cshperspect.a041183 |