دورية أكاديمية
أعرض في EDS

Marine Natural Products as Leads against SARS-CoV-2 Infection.

التفاصيل البيبلوغرافية
العنوان: Marine Natural Products as Leads against SARS-CoV-2 Infection.
المؤلفون: Chhetri BK; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Tedbury PR; Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Sweeney-Jones AM; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States., Mani L; Institute of Applied Sciences, University of South Pacific, Suva, Fiji., Soapi K; Institute of Applied Sciences, University of South Pacific, Suva, Fiji., Manfredi C; Department of Pediatrics, Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Sorscher E; Department of Pediatrics, Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Sarafianos SG; Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Kubanek J; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.; Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.; School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
المصدر: Journal of natural products [J Nat Prod] 2022 Mar 25; Vol. 85 (3), pp. 657-665. Date of Electronic Publication: 2022 Mar 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cincinnati, American Society of Pharmacognosy.
مواضيع طبية MeSH: Biological Products*/pharmacology , COVID-19 Drug Treatment*, Antiviral Agents/pharmacology ; Epithelial Cells ; Humans ; SARS-CoV-2
مستخلص: Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent that the global community lacks multipronged interventions to combat viral infection and disease. A major limitation is the paucity of antiviral drug options representing diverse molecular scaffolds and mechanisms of action. Here we report the antiviral activities of three distinct marine natural products─homofascaplysin A ( 1 ), (+)-aureol ( 2 ), and bromophycolide A ( 3 )─evidenced by their ability to inhibit SARS-CoV-2 replication at concentrations that are nontoxic toward human airway epithelial cells. These compounds stand as promising candidates for further exploration toward the discovery of novel drug leads against SARS-CoV-2.
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معلومات مُعتمدة: U19 TW007401 United States TW FIC NIH HHS
المشرفين على المادة: 0 (Antiviral Agents)
0 (Biological Products)
تواريخ الأحداث: Date Created: 20220315 Date Completed: 20220401 Latest Revision: 20230906
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8936055
DOI: 10.1021/acs.jnatprod.2c00015
PMID: 35290044
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-6025
DOI:10.1021/acs.jnatprod.2c00015