دورية أكاديمية
Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants.
العنوان: | Altered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants. |
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المؤلفون: | Bricker KM; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Obregon-Perko V; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Williams B; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Oliver D; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Uddin F; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Neja M; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Hopkins L; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Dashti A; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Jean S; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Wood JS; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Ehnert S; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Liang S; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Vanderford T; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Tharp GK; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Bosinger SE; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA., Schauer AP; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA., Mavigner M; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA., Cottrell ML; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA., Margolis D; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; Center for AIDS Research, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; UNC HIV Cure Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; Department of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA., Dunham RM; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; UNC HIV Cure Center, University of North Carolina at Chapel Hillgrid.10698.36, Chapel Hill, North Carolina, USA.; Qura Therapeutics, Chapel Hill, Research Triangle Park, North Carolina, USA.; HIV Drug Discovery, ViiV Healthcare, Research Triangle Park, North Carolina, USA., Chahroudi A; Department of Pediatrics, Emory University School of Medicinegrid.471395.d, Atlanta, Georgia, USA.; Yerkes National Primate Research Center, Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA.; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and Emory Universitygrid.471395.dgrid.189967.8grid.471395.dgrid.189967.8, Atlanta, Georgia, USA. |
المصدر: | Journal of virology [J Virol] 2022 Apr 13; Vol. 96 (7), pp. e0169921. Date of Electronic Publication: 2022 Mar 16. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
مواضيع طبية MeSH: | HIV Infections*/drug therapy , HIV-1*/genetics , Simian Acquired Immunodeficiency Syndrome*/drug therapy , Simian Acquired Immunodeficiency Syndrome*/immunology , Simian Immunodeficiency Virus*, Alkynes/pharmacokinetics ; Alkynes/pharmacology ; Alkynes/therapeutic use ; Animals ; Anti-Retroviral Agents/pharmacokinetics ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes ; Humans ; Macaca mulatta ; Oligopeptides/pharmacokinetics ; Oligopeptides/pharmacology ; Oligopeptides/therapeutic use ; Viral Load ; Virus Latency/drug effects ; Virus Replication |
مستخلص: | The "shock and kill" strategy for HIV-1 cure incorporates latency-reversing agents (LRA) in combination with interventions that aid the host immune system in clearing virally reactivated cells. LRAs have not yet been investigated in pediatric clinical or preclinical studies. Here, we evaluated an inhibitor of apoptosis protein (IAP) inhibitor (IAPi), AZD5582, that activates the noncanonical NF-κB (ncNF-κB) signaling pathway to reverse latency. Ten weekly doses of AZD5582 were intravenously administered at 0.1 mg/kg to rhesus macaque (RM) infants orally infected with SIV |
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معلومات مُعتمدة: | P30 AI050409 United States AI NIAID NIH HHS; P51 OD011132 United States OD NIH HHS; P30 CA138292 United States CA NCI NIH HHS; UM1 AI164567 United States AI NIAID NIH HHS; S10 OD026799 United States OD NIH HHS; R01 AI133706 United States AI NIAID NIH HHS; U24 OD011023 United States OD NIH HHS; P30 AI050410 United States AI NIAID NIH HHS; U42 OD011023 United States OD NIH HHS; UM1 AI164566 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: HIV; HIV cure; NHP; SIV; pediatric HIV |
المشرفين على المادة: | 0 (Alkynes) 0 (Anti-Retroviral Agents) 0 (N,N'-(2,2'-(hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-(2-cyclohexyl-2-(2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)) 0 (Oligopeptides) |
تواريخ الأحداث: | Date Created: 20220316 Date Completed: 20220415 Latest Revision: 20230317 |
رمز التحديث: | 20230320 |
مُعرف محوري في PubMed: | PMC9006931 |
DOI: | 10.1128/jvi.01699-21 |
PMID: | 35293766 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-5514 |
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DOI: | 10.1128/jvi.01699-21 |