دورية أكاديمية
Immune regulation by fungal strain diversity in inflammatory bowel disease.
| العنوان: | Immune regulation by fungal strain diversity in inflammatory bowel disease. |
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| المؤلفون: | Li XV; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Leonardi I; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Putzel GG; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Semon A; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Fiers WD; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Kusakabe T; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Lin WY; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA., Gao IH; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA., Doron I; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Gutierrez-Guerrero A; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., DeCelie MB; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Carriche GM; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Mesko M; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA., Yang C; Department of Pathology, Yale School of Medicine, Yale University, New Haven, CT, USA., Naglik JR; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK., Hube B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany.; Institute of Microbiology, FriedrichSchiller University, Jena, Germany., Scherl EJ; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.; The Jill Roberts Center for Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA., Iliev ID; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA. iliev@med.cornell.edu.; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. iliev@med.cornell.edu.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA. iliev@med.cornell.edu.; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA. iliev@med.cornell.edu. |
| المصدر: | Nature [Nature] 2022 Mar; Vol. 603 (7902), pp. 672-678. Date of Electronic Publication: 2022 Mar 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Fungi*/genetics , Fungi*/pathogenicity , Gastrointestinal Microbiome* , Inflammatory Bowel Diseases* , Microbiota* , Mycobiome*, Animals ; CRISPR-Cas Systems ; Candida albicans ; Genetic Variation ; Humans ; Immunity ; Inflammation ; Mammals |
| مستخلص: | The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation 1-6 . Although aberrant changes in the mycobiota have been linked to several diseases, including inflammatory bowel disease 3-9 , it is currently unknown whether fungal species captured by deep sequencing represent living organisms and whether specific fungi have functional consequences for disease development in affected individuals. Here we developed a translational platform for the functional analysis of the mycobiome at the fungal-strain- and patient-specific level. Combining high-resolution mycobiota sequencing, fungal culturomics and genomics, a CRISPR-Cas9-based fungal strain editing system, in vitro functional immunoreactivity assays and in vivo models, this platform enables the examination of host-fungal crosstalk in the human gut. We discovered a rich genetic diversity of opportunistic Candida albicans strains that dominate the colonic mucosa of patients with inflammatory bowel disease. Among these human-gut-derived isolates, strains with high immune-cell-damaging capacity (HD strains) reflect the disease features of individual patients with ulcerative colitis and aggravated intestinal inflammation in vivo through IL-1β-dependent mechanisms. Niche-specific inflammatory immunity and interleukin-17A-producing T helper cell (T (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.) |
| التعليقات: | Comment in: Nat Rev Gastroenterol Hepatol. 2022 May;19(5):280. doi: 10.1038/s41575-022-00613-x. (PMID: 35379940) Comment in: Gastroenterology. 2022 Jul;163(1):333-334. doi: 10.1053/j.gastro.2022.05.001. (PMID: 35525319) Comment in: Med. 2022 May 13;3(5):270-272. doi: 10.1016/j.medj.2022.04.011. (PMID: 35584642) Erratum in: Nature. 2022 Aug;608(7922):E21. doi: 10.1038/s41586-022-05102-4. (PMID: 35859182) |
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| معلومات مُعتمدة: | R37 DE022550 United States DE NIDCR NIH HHS; United Kingdom WT_ Wellcome Trust; F32 DK120228 United States DK NIDDK NIH HHS; R01 DK113136 United States DK NIDDK NIH HHS; R01 DK121977 United States DK NIDDK NIH HHS; R21 AI146957 United States AI NIAID NIH HHS; R01 AI163007 United States AI NIAID NIH HHS; 214229_Z_18_Z United Kingdom WT_ Wellcome Trust |
| تواريخ الأحداث: | Date Created: 20220317 Date Completed: 20220415 Latest Revision: 20240615 |
| رمز التحديث: | 20240615 |
| مُعرف محوري في PubMed: | PMC9166917 |
| DOI: | 10.1038/s41586-022-04502-w |
| PMID: | 35296857 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41586-022-04502-w |