دورية أكاديمية
أعرض في EDS

Nuclear translocation of vitellogenin in the honey bee ( Apis mellifera ).

التفاصيل البيبلوغرافية
العنوان: Nuclear translocation of vitellogenin in the honey bee ( Apis mellifera ).
المؤلفون: Salmela H; Organismal and Evolutionary Biology Research Program, University of Helsinki, Viikinkaari 1, 00014 Helsinki, FI Finland., Harwood GP; Department of Entomology, University of Illinois at Urbana-Champaign, 320 Morrill Hall 505 South Goodwin Avenue, Urbana, IL 61801 USA., Münch D; Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences, N-1432 Aas, Norway., Elsik CG; Division of Animal Sciences, University of Missouri, S108 Animal Sciences Research Center (ASRC), Colombia, MO 65211 USA., Herrero-Galán E; Centro Nacional de Biotecnología, Calle Darwin 3, 28049 Madrid, Spain., Vartiainen MK; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland., Amdam GV; Faculty of Environmental Sciences and Natural Resource Management, Norwegian University of Life Sciences, N-1432 Aas, Norway.; School of Life Sciences, Arizona State University, 427 East Tyler Mall, Tempe, AZ 85281 USA.
المصدر: Apidologie [Apidologie] 2022; Vol. 53 (1), pp. 13. Date of Electronic Publication: 2022 Mar 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Paris Country of Publication: France NLM ID: 100955724 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0044-8435 (Print) Linking ISSN: 00448435 NLM ISO Abbreviation: Apidologie Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Paris : Springer Paris
Original Publication: Paris : Arbeitsgemeinschaft der Institute für Bienenforschung [et] Institut national de la recherche agronomique, 1970-
مستخلص: Vitellogenin (Vg) is a conserved protein used by nearly all oviparous animals to produce eggs. It is also pleiotropic and performs functions in oxidative stress resistance, immunity, and, in honey bees, behavioral development of the worker caste. It has remained enigmatic how Vg affects multiple traits. Here, we asked whether Vg enters the nucleus and acts via DNA-binding. We used cell fractionation, immunohistology, and cell culture to show that a structural subunit of honey bee Vg translocates into cell nuclei. We then demonstrated Vg-DNA binding theoretically and empirically with prediction software and chromatin immunoprecipitation with sequencing (ChIP-seq), finding binding sites at genes influencing immunity and behavior. Finally, we investigated the immunological and enzymatic conditions affecting Vg cleavage and nuclear translocation and constructed a 3D structural model. Our data are the first to show Vg in the nucleus and suggest a new fundamental regulatory role for this ubiquitous protein.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13592-022-00914-9.
Competing Interests: Conflict of interestThe authors declare no competing interests.
(© The Author(s) 2022.)
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فهرسة مساهمة: Keywords: DNA binding; Vitellogenin; nuclear protein
تواريخ الأحداث: Date Created: 20220321 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8924143
DOI: 10.1007/s13592-022-00914-9
PMID: 35309709
قاعدة البيانات: MEDLINE
الوصف
تدمد:0044-8435
DOI:10.1007/s13592-022-00914-9