دورية أكاديمية
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Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.

التفاصيل البيبلوغرافية
العنوان: Childhood Threat Is Associated With Lower Resting-State Connectivity Within a Central Visceral Network.
المؤلفون: Banihashemi L; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Peng CW; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Rangarajan A; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Karim HT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Wallace ML; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Statistics, University of Pittsburgh, Pittsburgh, PA, United States., Sibbach BM; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Singh J; Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States., Stinley MM; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States., Germain A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Aizenstein HJ; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States.
المصدر: Frontiers in psychology [Front Psychol] 2022 Mar 03; Vol. 13, pp. 805049. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101550902 Publication Model: eCollection Cited Medium: Print ISSN: 1664-1078 (Print) Linking ISSN: 16641078 NLM ISO Abbreviation: Front Psychol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Pully, Switzerland : Frontiers Research Foundation
مستخلص: Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females ( n = 100; mean age = 27.28, SD = 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology.
Competing Interests: MW is a statistical consultant for Noctem, unrelated to this work. AG serves as CEO and holds equity in Rehat, LLC and has also served as a consultant for Jazz Pharmaceuticals, Inc., unrelated to this work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Banihashemi, Peng, Rangarajan, Karim, Wallace, Sibbach, Singh, Stinley, Germain and Aizenstein.)
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فهرسة مساهمة: Keywords: affective disorders; amygdala; bed nucleus of stria terminalis; childhood trauma; extended amygdala; hypothalamus; subgenual anterior cingulate cortex
تواريخ الأحداث: Date Created: 20220321 Latest Revision: 20220322
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8927539
DOI: 10.3389/fpsyg.2022.805049
PMID: 35310241
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-1078
DOI:10.3389/fpsyg.2022.805049