دورية أكاديمية
Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model.
| العنوان: | Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model. |
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| المؤلفون: | Mejorado-Molano FJ; Department of Pediatrics, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain., Sanz-Calvo ML; Centro de Salud Palma Norte, Madrid, Spain., Posada-Ayala A; Centro de Salud Embajadores, Madrid, Spain., Caballo-Roig N; Centro de Salud Embajadores, Madrid, Spain., Gavela-Pérez T; Department of Pediatrics, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain., Mahillo-Fernández I; Epidemiological Research Unit, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Madrid, Spain., Soriano-Guillén L; Department of Pediatrics, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Mar 03; Vol. 13, pp. 852422. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Adrenarche* , Puberty, Precocious*/diagnosis, Body Height ; Child ; Cohort Studies ; Female ; Humans ; Puberty |
| مستخلص: | Introduction: Idiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA. Materials and Methods: A cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable. Results: We obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36-165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R 2 value of 71%. Conclusions: Although slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mejorado-Molano, Sanz-Calvo, Posada-Ayala, Caballo-Roig, Gavela-Pérez, Mahillo-Fernández and Soriano-Guillén.) |
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| فهرسة مساهمة: | Keywords: adult height; adult height predictive models; idiopathic premature adrenarche; multiple regression analysis; target height |
| تواريخ الأحداث: | Date Created: 20220321 Date Completed: 20220425 Latest Revision: 20240821 |
| رمز التحديث: | 20240821 |
| مُعرف محوري في PubMed: | PMC8927636 |
| DOI: | 10.3389/fendo.2022.852422 |
| PMID: | 35311244 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2022.852422 |