دورية أكاديمية
Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes.
| العنوان: | Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes. |
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| المؤلفون: | Garcia-Gonzalez MA; Departamento de Farmacia, Benemerita Universidad Autonoma de Puebla, Laboratorio de Farmacia Clinica, Edificio FCQ10, Ciudad Universitaria, Col. Jardines de San Manuel, Puebla, Mexico., Vallejo-Ruiz V; Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica de Oriente, Laboratorio de Biología Molecular, Puebla, Mexico., Atonal-Flores F; Departamento de Fisiología, Benemérita Universidad Autónoma de Puebla, Facultad de Medicina, Metepec, Mexico., Flores-Hernandez J; Laboratorio de Neuromodulación, Benemerita Universidad Autonoma de Puebla, Fisiología, Puebla,Mexico., Torres-Ramírez O; Departamento de Farmacia, Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Químicas, Puebla, Mexico., Diaz-Fonsecae A; Departamento de Farmacia, Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Químicas, Puebla, Mexico., Perez Vizcaino F; Departamento de Farmacología y Toxicología, Universidad Complutense de Madrid, Escuela de Medicina, Puebla,Mexico., Lopez-Lopez JG; Departamento de Farmacia, Benemerita Universidad Autonoma de Puebla, Laboratorio de Farmacia Clinica, Edificio FCQ10, Ciudad Universitaria, Col. Jardines de San Manuel, Puebla, Mexico. |
| المصدر: | Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2022 May 19; Vol. 44 (4), pp. 355-365. Date of Electronic Publication: 2022 Mar 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, N.Y. : Marcel Dekker, Inc., c1993- |
| مواضيع طبية MeSH: | Hypertension, Pulmonary*/drug therapy , Hypertension, Pulmonary*/etiology , Hypertension, Pulmonary*/prevention & control , Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Type 1*/complications, Rats ; Male ; Animals ; Sildenafil Citrate/pharmacology ; Hypertrophy, Right Ventricular/etiology ; Hypertrophy, Right Ventricular/prevention & control ; Heart Rate ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Rats, Sprague-Dawley ; Disease Models, Animal |
| مستخلص: | Chronic treatment with sildenafil (SILD) is an effective protector on the development of cardiovascular complications of pulmonary hypertension (PH) and diabetes. However, to date, no studies have evaluated the effect of SILD on cardiopulmonary pathophysiology during PH secondary to type 1 diabetes. Aim: The present study aimed to evaluate the beneficial effects of chronic SILD treatment on pulmonary arterial pressure, right ventricular hypertrophy (RVH) and cardiac autonomic dysfunction in rats with PH secondary to diabetes. Metodology: Male Sprague Dawley rats were randomly distributed into the control group (saline), diabetic group (60 mg/kg with streptozotocin), SILD-treated control group (20 mg/kg) and SILD-treated diabetic group. Results: After 8 weeks the type 1 diabetic animals presented PH, endothelial dysfunction of the pulmonary arteries, electrocardiographic alterations, RVH and overexpression of phosphodiesterase type 5 in the heart. In type 1 diabetic animals, SILD treatment prevented the development of PH, endothelial dysfunction and RVH. SILD treatment also prevented alterations in the corrected QT period and heart rate variability and prevented overexpression of phosphodiesterase type 5. Conclusion: Our results indicate for the first time that SILD treatment prevents pulmonary arterial endothelial dysfunction, pulmonary hypertension, right ventricular hypertrophy and improves heart rate variability in type 1 diabetic rats. |
| فهرسة مساهمة: | Keywords: Sildenafil; cardiac autonomic neuropathy; diabetes mellitus; pulmonary hypertension; right ventricular hypertrophy |
| المشرفين على المادة: | BW9B0ZE037 (Sildenafil Citrate) EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5) |
| تواريخ الأحداث: | Date Created: 20220321 Date Completed: 20230526 Latest Revision: 20230526 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/10641963.2022.2050743 |
| PMID: | 35311436 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6006 |
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| DOI: | 10.1080/10641963.2022.2050743 |