دورية أكاديمية
أعرض في EDS

Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol.

التفاصيل البيبلوغرافية
العنوان: Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol.
المؤلفون: Driessen DAJJ; Department of Radiation Oncology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., de Gouw DJJM; Department of Surgery, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Stijns RCH; Department of Surgery, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Litjens G; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Israël B; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Philips BWJ; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Hermans JJ; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Dijkema T; Department of Radiation Oncology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Klarenbeek BR; Department of Surgery, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., van der Post RS; Department of Pathology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., van Engen-van Grunsven ACH; Department of Pathology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Brosens LAA; Department of Pathology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Veltien A; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Zámecnik P; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands., Scheenen TWJ; Department of Medical Imaging, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
المصدر: Methods and protocols [Methods Protoc] 2022 Mar 07; Vol. 5 (2). Date of Electronic Publication: 2022 Mar 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101720073 Publication Model: Electronic Cited Medium: Internet ISSN: 2409-9279 (Electronic) Linking ISSN: 24099279 NLM ISO Abbreviation: Methods Protoc Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2018]-
مستخلص: Background: In various cancer types, the first step towards extended metastatic disease is the presence of lymph node metastases. Imaging methods with sufficient diagnostic accuracy are required to personalize treatment. Lymph node metastases can be detected with ultrasmall superparamagnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI), but this method needs validation. Here, a workflow is presented, which is designed to compare MRI-visible lymph nodes on a node-to-node basis with histopathology.
Methods: In patients with prostate, rectal, periampullary, esophageal, and head-and-neck cancer, in vivo USPIO-enhanced MRI was performed to detect lymph nodes suspicious of harboring metastases. After lymphadenectomy, but before histopathological assessment, a 7 Tesla preclinical ex vivo MRI of the surgical specimen was performed, and in vivo MR images were radiologically matched to ex vivo MR images. Lymph nodes were annotated on the ex vivo MRI for an MR-guided pathological examination of the specimens.
Results: Matching lymph nodes of ex vivo MRI to pathology was feasible in all cancer types. The annotated ex vivo MR images enabled a comparison between USPIO-enhanced in vivo MRI and histopathology, which allowed for analyses on a nodal, or at least on a nodal station, basis.
Conclusions: A workflow was developed to validate in vivo USPIO-enhanced MRI with histopathology. Guiding the pathologist towards lymph nodes in the resection specimens during histopathological work-up allowed for the analysis at a nodal basis, or at least nodal station basis, of in vivo suspicious lymph nodes with corresponding histopathology, providing direct information for validation of in vivo USPIO-enhanced, MRI-detected lymph nodes.
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فهرسة مساهمة: Keywords: 7 Tesla; lymph node; magnetic resonance imaging; nodal staging; node-to-node correlation; pathology
تواريخ الأحداث: Date Created: 20220322 Latest Revision: 20220325
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8938816
DOI: 10.3390/mps5020024
PMID: 35314661
قاعدة البيانات: MEDLINE
الوصف
تدمد:2409-9279
DOI:10.3390/mps5020024