دورية أكاديمية
The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis.
| العنوان: | The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis. |
|---|---|
| المؤلفون: | Buerkli S; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland. simone.buerkli@gmail.com., Salvioni L; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland., Koller N; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland., Zeder C; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland., Teles MJ; Clinical Pathology, S. João University Hospital Center, Porto, Portugal., Porto G; Clinical Hematology, Santo António Hospital, Porto University Hospital Center (CHUP), Porto, Portugal.; Abel Salazar Institute for Biomedical Sciences (ICBAS), Porto, Portugal.; Institute of Research and Innovation in Health Sciences (i3S) of the University of Porto, Porto, Portugal., Habermann JH; Division of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland., Dubach IL; Division of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland., Vallelian F; Division of Internal Medicine, University Hospital of Zurich, Zurich, Switzerland., Frey BM; Blood Transfusion Service, Swiss Red Cross, Schlieren, Switzerland., Moretti D; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland.; Department of Health, Swiss Distance University of Applied Sciences, Regensdorf/Zurich, Switzerland., Baumgartner J; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland., Zimmermann MB; Laboratory of Human Nutrition, Institute of Food Nutrition and Health, Department of Health Science and Technology, Swiss Federal Institute of Technology (ETH Zurich), LFV D27.2, Schmelzbergstrasse 7, CH8092, Zurich, Switzerland. |
| المصدر: | European journal of nutrition [Eur J Nutr] 2022 Sep; Vol. 61 (6), pp. 2967-2977. Date of Electronic Publication: 2022 Mar 23. |
| نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Darmstadt, Germany : Steinkopff, 1999- |
| مواضيع طبية MeSH: | Hemochromatosis*/drug therapy , Hemochromatosis*/genetics , Hemochromatosis*/metabolism, Adult ; Cross-Over Studies ; Hemochromatosis Protein ; Histocompatibility Antigens Class I/genetics ; Humans ; Iron ; Iron, Dietary ; Polyphenols/pharmacology ; Powders ; Single-Blind Method ; Tea |
| مستخلص: | Objectives: We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). Methods: We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into erythrocytes. Results: Black tea powder, cocoa powder and grape juice extract most effectively precipitated iron in vitro. A PPS mixture of these three extracts precipitated ~ 80% of iron when 2 g was added to a 500 g iron solution containing 20 µg Fe/g. In the iron absorption study, the PPS reduced FIA by ~ 40%: FIA from the meal consumed with the PPS was lower (3.01% (1.60, 5.64)) than with placebo (5.21% (3.92, 6.92)) (p = 0.026)), and FIA from the test drink with the PPS was lower (10.3% (7.29 14.6)) than with placebo (16.9% (12.8 22.2)) (p = 0.002). Conclusion: Our results indicate that when taken with meals, this natural PPS can decrease dietary iron absorption, and might thereby reduce body iron accumulation and the frequency of phlebotomy in patients with HH. Trial Registry: clinicaltrials.gov (registration date: 9.6.2019, NCT03990181). (© 2022. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Hereditary hemochromatosis; Iron absorption; Polyphenols; Reducing dietary iron absorption; Supplement |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03990181 |
| المشرفين على المادة: | 0 (Hemochromatosis Protein) 0 (Histocompatibility Antigens Class I) 0 (Iron, Dietary) 0 (Polyphenols) 0 (Powders) 0 (Tea) E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20220323 Date Completed: 20220811 Latest Revision: 20221003 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9363374 |
| DOI: | 10.1007/s00394-022-02829-8 |
| PMID: | 35320401 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00394-022-02829-8 |