دورية أكاديمية
أعرض في EDS

Development and Evaluation of Ginkgo biloba /Sodium Alginate Nanocomplex Gel as a Long-Acting Formulation for Wound Healing.

التفاصيل البيبلوغرافية
العنوان: Development and Evaluation of Ginkgo biloba /Sodium Alginate Nanocomplex Gel as a Long-Acting Formulation for Wound Healing.
المؤلفون: Md S; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center of Excellence for Drug Research & Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Abdullah S; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alhakamy NA; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center of Excellence for Drug Research & Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Shaik RA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Eldakhakhny BM; Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Omar UM; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Princess Dr. Najla Bint Saud Al- Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Eid BG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Ansari AR; Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alamoudi AJ; Center of Excellence for Drug Research & Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Rizg WY; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center of Excellence for Drug Research & Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia., Venkateswaran SP; Department of Pathology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia., Rashid MA; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.
المصدر: Gels (Basel, Switzerland) [Gels] 2022 Mar 19; Vol. 8 (3). Date of Electronic Publication: 2022 Mar 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101696925 Publication Model: Electronic Cited Medium: Internet ISSN: 2310-2861 (Electronic) Linking ISSN: 23102861 NLM ISO Abbreviation: Gels Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2015]-
مستخلص: The aim of the study was to develop and evaluate the Ginkgo biloba nanocomplex gel (GKNG) as a long-acting formulation for the wound healing potential. Pharmaceutical analysis showed an average particle size of 450.14 ± 36.06 nm for GKNG, zeta potential +0.012 ± 0.003 mV, and encapsulation efficiency 91 ± 1.8%. The rheological analysis also showed the optimum diffusion rate and viscosity needed for topical drug delivery. Fourier transform infrared spectroscopy (FTIR), powder X-ray diffractometry (PXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis further confirmed the success of GKNG. The in vivo study showed increments in the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and a lower level of lipid peroxidation (MDA) after GKNG treatment. The GKNG group showed upregulations in collagen type I, as alpha 1 collagen (COL1A1), and collagen type IV, as alpha 1 collagen (COL4A1). Furthermore, the in vivo study showed increments in hydroxyproline, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta 1 (TGF-β1) after the GKNG. Additionally, GKNG effectively increased the wound contraction compared to GK gel and sodium alginate (SA) gel. Based on the in vitro and in vivo evaluation, GKNG effectively accelerated wound healing by modulation of antioxidant enzymes, collagens, angiogenic factors, and TGF-β1.
References: Life (Basel). 2021 Jul 07;11(7):. (PMID: 34357037)
Exp Hematol. 2020 Feb;82:24-32. (PMID: 31987924)
Stem Cell Res Ther. 2020 May 24;11(1):198. (PMID: 32448395)
Int J Mol Sci. 2020 Feb 07;21(3):. (PMID: 32046094)
Pharmacol Res. 2022 Jan;175:105993. (PMID: 34801680)
Exp Neurol. 2020 Dec;334:113464. (PMID: 32941795)
Int Wound J. 2022 Jan;19(1):211-221. (PMID: 34105873)
ACS Appl Mater Interfaces. 2018 Apr 25;10(16):13304-13316. (PMID: 29607644)
Eur J Pharmacol. 2019 Nov 15;863:172666. (PMID: 31541628)
Curr Pharm Des. 2020;26(36):4551-4568. (PMID: 32532188)
Int J Pharm. 2022 Feb 5;613:121406. (PMID: 34968681)
J Oral Sci. 2020;62(3):293-297. (PMID: 32581176)
Skin Pharmacol Physiol. 2011;24(3):113-26. (PMID: 21242718)
Adv Healthc Mater. 2021 Aug;10(16):e2100477. (PMID: 34174163)
Biomed Res Int. 2021 Oct 13;2021:6474706. (PMID: 34692837)
J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713)
Gels. 2021 Nov 30;7(4):. (PMID: 34940303)
Int J Pharm. 2021 Dec 15;610:121179. (PMID: 34648878)
Life Sci. 2020 Oct 15;259:118246. (PMID: 32791151)
Mol Biol Rep. 2020 Mar;47(3):1821-1834. (PMID: 31989428)
Br J Cancer. 2009 May 19;100(10):1549-57. (PMID: 19384296)
Mater Sci Eng C Mater Biol Appl. 2021 Jan;120:111671. (PMID: 33545836)
Physiol Rev. 2019 Jan 1;99(1):665-706. (PMID: 30475656)
Expert Opin Drug Deliv. 2008 Dec;5(12):1323-34. (PMID: 19040395)
Biofactors. 2020 Nov;46(6):963-973. (PMID: 32941697)
Connect Tissue Res. 2011 Jun;52(3):218-25. (PMID: 20932173)
Colloids Surf B Biointerfaces. 2020 Nov;195:111263. (PMID: 32717624)
Int J Biol Macromol. 2019 Aug 1;134:91-99. (PMID: 31067486)
Clin Plast Surg. 1977 Jul;4(3):325-46. (PMID: 328211)
Life Sci. 2018 Oct 15;211:172-181. (PMID: 30227132)
EMBO Rep. 2020 Apr 3;21(4):e49115. (PMID: 32080965)
J Mater Chem B. 2020 Aug 19;8(32):7062-7075. (PMID: 32756718)
Pharm Dev Technol. 2020 Jul;25(6):666-675. (PMID: 32067531)
Front Cell Dev Biol. 2020 Jun 26;8:528. (PMID: 32671072)
Eur J Pharm Biopharm. 2021 Jun;163:223-239. (PMID: 33864904)
J Ethnopharmacol. 2000 Nov;73(1-2):15-30. (PMID: 11025135)
Talanta. 1971 Aug;18(8):761-6. (PMID: 18960943)
Gels. 2021 Dec 20;7(4):. (PMID: 34940336)
معلومات مُعتمدة: RG-6-166-42 King Abdulaziz university
فهرسة مساهمة: Keywords: Ginkgo biloba extract; alginate topical delivery; gels; nanocomplex; sodium alginate
تواريخ الأحداث: Date Created: 20220324 Latest Revision: 20220329
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8949612
DOI: 10.3390/gels8030189
PMID: 35323302
قاعدة البيانات: MEDLINE
الوصف
تدمد:2310-2861
DOI:10.3390/gels8030189