دورية أكاديمية
أعرض في EDS

The Profile of MicroRNA Expression in Bone Marrow in Non-Hodgkin's Lymphomas.

التفاصيل البيبلوغرافية
العنوان: The Profile of MicroRNA Expression in Bone Marrow in Non-Hodgkin's Lymphomas.
المؤلفون: Veryaskina YA; Laboratory of Gene Engineering, Institute of Cytology and Genetics, SB RAS, 630090 Novosibirsk, Russia., Titov SE; Laboratory of Molecular Genetics, Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, SB RAS, 630090 Novosibirsk, Russia.; AO Vector-Best, 630117 Novosibirsk, Russia., Kovynev IB; Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University, 630091 Novosibirsk, Russia., Pospelova TI; Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University, 630091 Novosibirsk, Russia., Zhimulev IF; Laboratory of Molecular Genetics, Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, SB RAS, 630090 Novosibirsk, Russia.
المصدر: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2022 Mar 03; Vol. 12 (3). Date of Electronic Publication: 2022 Mar 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101658402 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4418 (Print) Linking ISSN: 20754418 NLM ISO Abbreviation: Diagnostics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of malignant lymphomas that can occur in both lymph nodes and extranodal sites. Bone marrow (BM) is the most common site of extranodal involvement in NHL. The objective of this study is to determine the unique profile of miRNA expression in BM affected by NHL, with the possibility of a differential diagnosis of NHL from reactive BM changes and acute leukemia (AL). A total of 180 cytological samples were obtained by sternal puncture and aspiration biopsy of BM from the posterior iliac spine. All the cases were patients before treatment initiation. The study groups were NHL cases ( n = 59) and AL cases (acute lymphoblastic leukemia ( n = 25) and acute myeloid leukemia ( n = 49)); the control group consisted of patients with non-cancerous blood diseases (NCBDs) ( n = 48). We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD. Therefore, we conclude that analysis of miRNA expression levels may be a promising tool for early diagnosis of NHL.
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معلومات مُعتمدة: 19-34-60024 Russian Foundation for Basic Research
فهرسة مساهمة: Keywords: Non-Hodgkin’s lymphomas; acute leukemia; bone marrow; let-7a; miRNA-124; microRNA
تواريخ الأحداث: Date Created: 20220325 Latest Revision: 20220329
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8947746
DOI: 10.3390/diagnostics12030629
PMID: 35328182
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4418
DOI:10.3390/diagnostics12030629