دورية أكاديمية
أعرض في EDS

Compartmentalized Innate Immune Response of Human Fetal Membranes against Escherichia coli Choriodecidual Infection.

التفاصيل البيبلوغرافية
العنوان: Compartmentalized Innate Immune Response of Human Fetal Membranes against Escherichia coli Choriodecidual Infection.
المؤلفون: Olmos-Ortiz A; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Hernández-Pérez M; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Flores-Espinosa P; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Sedano G; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Helguera-Repetto AC; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Villavicencio-Carrisoza Ó; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Valdespino-Vazquez MY; Departamento de Anatomía Patológica, INPer, Mexico City 11000, Mexico., Flores-Pliego A; Departamento de Inmunobioquímica, Instituto Nacional de Perinatología (INPer), Mexico City 11000, Mexico., Irles C; Departamento de Fisiología y Desarrollo Celular, INPer, Mexico City 11000, Mexico., Rivas-Santiago B; Unidad de Investigación Médica IMSS Zacatecas, Zacatecas 98000, Mexico., Moreno-Verduzco ER; Subdirección de Auxiliares de Diagnóstico, INPer, Mexico City 11000, Mexico., Díaz L; Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico., Zaga-Clavellina V; Departamento de Fisiología y Desarrollo Celular, INPer, Mexico City 11000, Mexico.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 10; Vol. 23 (6). Date of Electronic Publication: 2022 Mar 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: beta-Defensins*/metabolism , Escherichia coli Infections*/metabolism , Premature Birth*/metabolism, Female ; Humans ; Infant, Newborn ; Pregnancy ; Escherichia coli/metabolism ; Extraembryonic Membranes/metabolism ; Immunity, Innate
مستخلص: An infectious process into the uterine cavity represents a major endangered condition that compromises the immune privilege of the maternal-fetal unit and increases the risk for preterm birth (PTB) and premature rupture of membranes (PROM). Fetal membranes are active secretors of antimicrobial peptides (AMP), which limit bacterial growth, such as Escherichia coli . Nevertheless, the antibacterial responses displayed by chorioamniotic membranes against a choriodecidual E. coli infection have been briefly studied. The objective of this research was to characterize the profile of synthesis, activity, and spatial distribution of a broad panel of AMPs produced by fetal membranes in response to E. coli choriodecidual infection. Term human chorioamniotic membranes were mounted in a two independent compartment model in which the choriodecidual region was infected with live E. coli (1 × 10 5 CFU/mL). Amnion and choriodecidual AMP tissue levels and TNF-α and IL-1β secretion were measured by the enzyme-linked immunosorbent assay. The passage of bacterium through fetal membranes and their effect on structural continuity was followed for 24 h. Our results showed that E. coli infection caused a progressive mechanical disruption of the chorioamniotic membranes and an activated inflammatory environment. After the challenge, the amnion quickly (2-4 h) induced production of human beta defensins (HBD)-1, HBD-2, and LL-37. Afterwards (8-24 h), the amnion significantly produced HBD-1, HBD-2, HNP-1-3, S100A7, sPLA2, and elafin, whereas the choriodecidua induced LL-37 synthesis. Therefore, we noticed a temporal- and tissue-specific pattern regulation of the synthesis of AMPs by infected fetal membranes. However, fetal membranes were not able to contain the collagen degradation or the bacterial growth and migration despite the battery of produced AMPs, which deeply increases the risk for PTB and PROM. The mixture of recombinant HBDs at low concentrations resulted in increased bactericidal activity compared to each HBD alone in vitro, encouraging further research to study AMP combinations that may offer synergy to control drug-resistant infections in the perinatal period.
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معلومات مُعتمدة: 212250-3210-21205-01-15 Consejo Nacional de Ciencia y Tecnología; CB-242162 Consejo Nacional de Ciencia y Tecnología
فهرسة مساهمة: Keywords: alpha defensins; antimicrobial peptides; beta defensins; collagen degradation; genitourinary infection; innate defense; innate immunity; maternal–fetal interface
المشرفين على المادة: 0 (beta-Defensins)
تواريخ الأحداث: Date Created: 20220325 Date Completed: 20221227 Latest Revision: 20221227
رمز التحديث: 20221228
مُعرف محوري في PubMed: PMC8949057
DOI: 10.3390/ijms23062994
PMID: 35328414
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23062994